{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:18:10Z","timestamp":1772392690866,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Distal intestinal obstruction syndrome (DIOS) and constipation in cystic fibrosis (CF) are conditions associated with impaction and\/or obstruction by abnormally viscid mucofaecal material within the intestinal lumen. Dehydration has been proposed as a risk factor for DIOS and constipation in CF. The study primarily aimed to determine whether warmer ambient temperature and lower rainfall are risk factors for DIOS and constipation in CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hospitalisations for DIOS (incomplete or complete) and\/or constipation were retrospectively identified (2000\u20132012). Genotype, phenotype, temperatures and rainfall data (for the week preceding and season of hospitalisation) were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven DIOS (59.3% incomplete; 40.7% complete) and 44 constipation admissions were identified. All admitted patients were pancreatic insufficient. Meconium ileus was significantly more likely in DIOS than constipation (64.7% vs. 33.3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.038) and in complete than incomplete DIOS (100% vs. 57.1%; <jats:italic>P<\/jats:italic>\u2009=\u20090.04). The maximum temperature of the week before DIOS admission (mean (standard deviation)\u2009=\u200928.0 (5.8)\u2009\u00b0C) was significantly higher than the maximum temperature of the season of admission (25.2 (3.4)\u2009\u00b0C; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Similarly, the maximum temperature of the week before hospitalisation for constipation (mean (standard deviation)\u2009=\u200927.9 (6.3)\u2009\u00b0C) was significantly warmer compared with the season of admission (24.0 (4.1)\u2009\u00b0C; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). There were no significant differences between levels of rainfall during the week before hospitalisation and the season of admission for both DIOS and constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Relatively high ambient temperature may play a role in the pathogenesis of DIOS and constipation in CF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13096","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T16:02:55Z","timestamp":1462377775000},"page":"430-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["High ambient temperature and risk of intestinal obstruction in cystic fibrosis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-0926","authenticated-orcid":false,"given":"Chee Y","family":"Ooi","sequence":"first","affiliation":[{"name":"Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Gastroenterology Sydney Children's Hospital Randwick  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Jeyaruban","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Lau","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamarah","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Sydney Children's Hospital Randwick  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Matson","sequence":"additional","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Department of Nutrition and Dietetics The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott C","family":"Bell","sequence":"additional","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Queensland Children's Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E","family":"Adams","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Paediatric Surgery Sydney Children's Hospital Randwick  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Gastroenterology Sydney Children's Hospital Randwick  Randwick New South Wales 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