{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:42:03Z","timestamp":1791196923292,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T00:00:00Z","timestamp":1464393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2016,10]]},"abstract":"\n Aim<\/jats:title>\n The aim of this study was to evaluate the clinical presentation, risk factors, complications, treatment and outcomes of cholelithiasis in children.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Children with cholelithiasis were reviewed for demographic information, predisposing factors, presenting symptoms, laboratory findings, complications, treatment and outcome, retrospectively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 254 children with cholelithiasis (mean age: 8.9 \u00b1 5.2 years) were recruited to the study. Girls (52.8%) were significantly older than boys (\n P<\/jats:italic>\n < 0.001). Symptomatic patients (59%) were significantly older than asymptomatic patients (\n P<\/jats:italic>\n = 0.002). Abdominal pain was the most frequent symptom. No risk factors were identified in 56.6% of the patients. Ceftriaxone (20%) was the most commonly associated risk factor. At presentation, at least one of the following complications was seen in 14.1% of patients: cholecystitis (10.9%), obstructive jaundice (2.7%), pancreatitis (1.96%) and cholangitis (1.2%). There was no relationship between gallstone size and symptoms, aetiological factors and complications. The cholelithiasis dissolution rate was higher in younger children (\n P<\/jats:italic>\n = 0.032), in those with biliary sludge (\n P<\/jats:italic>\n < 0.0001) and ceftriaxone\u2010related cholelithiasis (\n P<\/jats:italic>\n < 0.001). Haemolytic anaemia (\n P<\/jats:italic>\n = 0.001) and older age (\n P<\/jats:italic>\n = 0.002) were associated with stable stones. Ursodeoxycholic acid was administered to 94.4% of patients at presentation. Twenty\u2010nine patients underwent cholecystectomy, and seven patients underwent endoscopic retrograde cholangiopancreotography. Patients who were symptomatic at presentation had significantly more frequent symptoms at follow\u2010up (\n P<\/jats:italic>\n < 0.001)\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dissolution rate of cholelithiasis was higher in younger children, biliary sludge formation and ceftriaxone\u2010related cholelithiasis but lower in older children and haemolytic anaemia\u2010related cholelithiasis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.13235","type":"journal-article","created":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T11:06:40Z","timestamp":1464433600000},"page":"944-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Risk factors, complications and outcome of cholelithiasis in children: A retrospective, single\u2010centre review"],"prefix":"10.1111","volume":"52","author":[{"given":"Ceyda","family":"Tuna Kirsaclioglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Ankara Child Health and Diseases Hematology\u2010Oncology Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"\u00c7uhac\u0131 \u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Well Child Clinic Ankara Child Health and Diseases Hematology\u2010Oncology Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Radiology Ankara Child Health and Diseases Hematology\u2010Oncology Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Akb\u0131y\u0131k","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Ankara Child Health and Diseases Hematology\u2010Oncology Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamir","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Child Health and Diseases Hematology\u2010Oncology Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahattin","family":"Tun\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ankara Child Health and Diseases Hematology\u2010Oncology Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200010000-00015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b99c72"},{"key":"e_1_2_8_4_1","first-page":"85","article-title":"Prevalence of cholelithiasis in children \u2013 a hospital\u2010based observation","volume":"24","author":"Ganesh R","year":"2005","journal-title":"Indian. 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