{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:23:28Z","timestamp":1760909008745},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T00:00:00Z","timestamp":1472256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Poor post\u2010natal growth is related to later morbidity and poor cognitive development in preterm infants. We investigated the relationship between plasma insulin\u2010like growth factor 1 (<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101), leptin, active ghrelin levels and post\u2010natal growth in preterm infants small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101, leptin and active ghrelin levels were measured at birth and at 2, 4, 6 and 8 weeks after birth in 42 very low birthweight (<jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content>) infants (born between 27 and 31 weeks of gestation), including 14 <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> infants with extrauterine growth restriction (<jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content>), 6 <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> infants without <jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content> and 22 appropriate\u2010for\u2010gestational\u2010age infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At birth, <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 levels in <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> infants without <jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content> did not differ significantly from those in <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> infants with <jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content>. However, <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 levels in <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> infants without <jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content> were as high as those observed in appropriate\u2010for\u2010gestational\u2010age infants and were significantly different from those in <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> infants with <jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content> at 4 and 8 weeks of age. Leptin and ghrelin levels did not differ significantly among the three groups at any time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 is related to catch\u2010up growth in <jats:styled-content style=\"fixed-case\">SGA VLBW<\/jats:styled-content> infants during neonatal intensive care unit admission; however, this does not appear to be the case for leptin and ghrelin. <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 level monitoring may be useful for predicting <jats:styled-content style=\"fixed-case\">EUGR<\/jats:styled-content> in preterm <jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content> infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13307","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T12:02:43Z","timestamp":1472299363000},"page":"62-67","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between insulin\u2010like growth factor 1, leptin and ghrelin levels and catch\u2010up growth in small for gestational age infants of 27\u201331 weeks during neonatal intensive care unit admission"],"prefix":"10.1111","volume":"53","author":[{"given":"Natsuki","family":"Ohkawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naho","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,27]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0763"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0211"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1352"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.5.986"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.280"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00276.x"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00008"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0844"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.1016"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.08.005"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.5.3935"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.10.4321"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.10.8490"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01516.x"},{"key":"e_1_2_8_1_18_1","first-page":"1271","article-title":"[Revised birth size standards by gestational age for Japanese neonates","volume":"114","author":"Itabashi K","year":"2010","journal-title":"Jpn. 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