{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:24:40Z","timestamp":1764174280335},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2016,9,4]],"date-time":"2016-09-04T00:00:00Z","timestamp":1472947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004702","name":"Baxter International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002066","name":"GlaxoSmithKline foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP0884126"],"award-info":[{"award-number":["LP0884126"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Influenza causes a substantial burden in young children. Vaccine efficacy (<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>) data are limited in this age group. We examined trivalent influenza vaccine (<jats:styled-content style=\"fixed-case\">TIV<\/jats:styled-content>) efficacy and safety in young children attending childcare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, randomised controlled trial in children aged 6 to &lt;48\u2009months was conducted with recruitment from Sydney childcare centres in 2011. Children were randomised to receive two doses of <jats:styled-content style=\"fixed-case\">TIV<\/jats:styled-content> or control hepatitis A vaccine. Efficacy was evaluated against polymerase chain reaction\u2010confirmed influenza using parent\u2010collected nose\/throat swabs during influenza\u2010like\u2010illness. Safety outcomes were assessed during 6 months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven children were allocated to influenza vaccine and 67 to control; all completed the study. The influenza attack rate was 1.8 vs 13.4% in the <jats:styled-content style=\"fixed-case\">TIV<\/jats:styled-content> and control groups, respectively; <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content> 87% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u201398%). For children aged 24 to &lt;48\u2009months, 0 vs 8 (18.6%) influenza infections occurred in the <jats:styled-content style=\"fixed-case\">TIV<\/jats:styled-content> and control groups respectively, giving a <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content> of 100% (16\u2013100%). Efficacy was not shown in children 6 to &lt;24\u2009months, probably due to insufficient power. Injection site and systemic adverse events were mostly mild to moderate with no significant differences, apart from more mild diarrhoea following dose 2 in <jats:styled-content style=\"fixed-case\">TIV<\/jats:styled-content> recipients (11.8 vs 0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Influenza vaccine appeared efficacious in the subgroup of children aged 24 to &lt;48\u2009months, although caution is required due to the small number of participants. There were no serious adverse events and most parents would vaccinate again. Influenza vaccination in a childcare setting could be valuable and a larger confirmatory study would be helpful.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13313","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T03:11:16Z","timestamp":1473045076000},"page":"47-54","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Influenza vaccine efficacy in young children attending childcare: A randomised controlled trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Jean P","family":"Li\u2010Kim\u2010Moy","sequence":"first","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehui K","family":"Yin","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Heron","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Leask","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B","family":"Lambert","sequence":"additional","affiliation":[{"name":"UQ Child Health Research Centre The University of Queensland  Brisbane Queensland Australia"},{"name":"Queensland Paediatric Infectious Diseases Laboratory Queensland Children's Medical Research Institute, Children's Health Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nissen","sequence":"additional","affiliation":[{"name":"Queensland Paediatric Infectious Diseases Laboratory Queensland Children's Medical Research Institute, Children's Health Queensland  Brisbane Queensland Australia"},{"name":"Lady Cilento Children's Hospital The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Sloots","sequence":"additional","affiliation":[{"name":"UQ Child Health Research Centre The University of Queensland  Brisbane Queensland Australia"},{"name":"Queensland Paediatric Infectious Diseases Laboratory Queensland Children's Medical Research Institute, Children's Health Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Booy","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Microbiology and Infectious Diseases The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1255"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3280ad4687"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008","volume":"57","author":"Fiore AE","year":"2008","journal-title":"MMWR Recomm. 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