{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:24:36Z","timestamp":1789161876281,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T00:00:00Z","timestamp":1472256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to describe the clinical epidemiology of <jats:italic>Staphylococcus aureus<\/jats:italic> bacteraemia (SAB) at a large, tertiary\/quaternary children's hospital in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of SAB cases at the Children's Hospital at Westmead (CHW) over 5 years; 2006\u20132011. We compared frequency, clinical profile and outcomes of SAB with published data from CHW; 1994\u20131998. We compared health\u2010care associated with community\u2010associated (HCA\u2010SAB and CA\u2010SAB; defined epidemiologically) and methicillin\u2010resistant with methicillin susceptible <jats:italic>S. aureus<\/jats:italic> (MRSA and MSSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 174 episodes of paediatric SAB with an average annual admission rate of 1.3\/1000 which has not increased compared with a decade earlier. Half of the cases (49%) were CA\u2010SAB; 18% were MRSA. The proportion of CA\u2010MRSA bacteraemia (22%) has increased. The proportion of SAB associated with central venous access devices (CVADs; 40%) has increased. CA\u2010SAB cases were more likely to present with a tissue focus of disease (e.g. osteo\u2010articular, pneumonia) and often required surgery. HCA\u2010SAB less frequently required surgery, a minority is MRSA, and vascular device intervention (removal, sterilisation) is common. Six cases (4%) of infective endocarditis (IE) were identified; three with a history of congenital heart disease, two with CVADs <jats:italic>in situ<\/jats:italic>. There were no deaths in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over an 18\u2010year period, the proportion of SAB due to CA\u2010MRSA and SAB associated with CVADs has increased. Categorisation of SAB as HCA and CA reveals two broad phenotypes of paediatric SAB. SAB in children is infrequently associated with IE. The health\u2010care burden of paediatric SAB is considerable', but mortality is low.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13329","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T12:16:36Z","timestamp":1472300196000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Paediatric <i>Staphylococcus aureus<\/i> bacteraemia: A single\u2010centre retrospective cohort"],"prefix":"10.1111","volume":"53","author":[{"given":"Jessica C","family":"Roediger","sequence":"first","affiliation":[{"name":"Department of General Medicine The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C","family":"Outhred","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Shadbolt","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Canberra Hospital  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N","family":"Britton","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Discipline of Paediatrics and Child Health, Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70285-1"},{"key":"e_1_2_8_3_1","volume-title":"Staphylococcus Aureus Bacteraemia in Australian Public Hospitals 2013\u201314: Australian Hospital Statistics","author":"Australian Institute of Health and Welfare","year":"2014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600810026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03903.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2061"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000261112.53035.4c"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00787.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000485"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)71003-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02449.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.11.185"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000195"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.12.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/16.5.276"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu410"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200109000-00009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.074229"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092760"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1112"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00081-09"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12255"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bpo.0000242431.91489.b4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e318186eb4b"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12347"},{"key":"e_1_2_8_27_1","unstructured":"O'GradyNP AlexanderM BurnsLAet al. Guidelines for the prevention of intravascular catheter\u2010related infections.Am. J. Infect. Control.2011;39(4 Suppl. 1): S1\u201334."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir138"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/676533"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2014.07.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.026781"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/430312"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0566"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-05"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1030"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir034"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70166-4"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1542\/peds.2004-1152","article-title":"Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia","volume":"115","author":"Valente AM","year":"2005","journal-title":"Pediatrics"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318165c884"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31816b78c8"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.9743"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000298"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078396"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.13329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.13329","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.13329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T18:34:40Z","timestamp":1696185280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.13329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,27]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/jpc.13329"],"URL":"https:\/\/doi.org\/10.1111\/jpc.13329","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,27]]},"assertion":[{"value":"2015-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}