{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:12:55Z","timestamp":1789103575696,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to analyse the effect of delayed diagnosis on mortality rates, and evaluate the role of delayed diagnosis as a new prognostic factor in patients with oesophageal atresia (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>), especially in developing countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The records of 80 consecutive patients with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> (2008\u20132013) were reviewed. Patients were divided into two groups according to the time of diagnosis. As we demonstrated the effect of delayed diagnosis on mortality, we decided to develop a new classification that will be utilised to predict the prognosis of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>. The discrimination ability of the new prognostic classification was compared with those of the Waterston, Montreal and Spitz classifications using the area under the curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The parameters of the new prognostic classification were birth weight less than 2000 g, the presence of major cardiac\/life\u2010threatening anomalies and delay in diagnosis. Class I consisted of patients with none or one of these parameters. Class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> consisted of patients with two or three of these parameters. The area under the curve of the new classification was better than those of the other classifications in determining the prognosis of patients with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Delayed diagnosis of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> significantly led to morbidity and mortality. Although delayed diagnosis is not a characteristic of newborn or a marker of severity for <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> and is a health care system issue in developing countries, we here point out that it is a prognostic factor in its own right. Our new classification has a superior discriminatory ability compared to the above\u2010mentioned classifications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13354","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T13:23:26Z","timestamp":1476278606000},"page":"1090-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Delayed diagnosis: An important prognostic factor for oesophageal atresia in developing countries"],"prefix":"10.1111","volume":"52","author":[{"given":"Suleyman Cuneyt","family":"Karakus","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Faculty of Medicine, University of Gaziantep  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent Hayri","family":"Ozokutan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Faculty of Medicine, University of Gaziantep  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unal","family":"Bakal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Faculty of Medicine, University of Firat  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Faculty of Medicine, University of Gaziantep  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sarac","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Faculty of Medicine, University of Firat  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seval","family":"Kul","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Faculty of Medicine, University of Gaziantep  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kazez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Faculty of Medicine, University of Firat  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"672","article-title":"Congenital atresia of osephagus with tracheoesophageal fistula. 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