{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:45:03Z","timestamp":1788669903316,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Aim<\/jats:title>Biliary atresia (BA<\/jats:styled-content>) literature has focussed on the relationship between age at Kasai procedure (KP<\/jats:styled-content>) and post\u2010KP<\/jats:styled-content> outcomes. This study primarily examines post\u2010KP<\/jats:styled-content> outcomes including, 6\u2010month normalisation of bilirubin, 5\u2010year native liver survival (NLS<\/jats:styled-content>), development of portal hypertension (PHT<\/jats:styled-content>) and incidence of ascending cholangitis at a single tertiary paediatric centre in Australia. The study also evaluated prognostic factors which may influence these aforementioned outcomes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective chart review of all BA<\/jats:styled-content> cases between 1999 and 2014. Age at KP<\/jats:styled-content>, liver biopsy results, use of ursodeoxycholic acid or prophylactic antibiotics and occurrence of PHT<\/jats:styled-content> and ascending cholangitis post\u2010KP<\/jats:styled-content> were recorded and related to the primary post\u2010KP<\/jats:styled-content> outcome measures.<\/jats:p><\/jats:sec>Results<\/jats:title>\nBA<\/jats:styled-content> was diagnosed in 29 patients. Twenty\u2010four of 29 patients underwent KP<\/jats:styled-content>. Median age at KP<\/jats:styled-content> was 68 days (29\u2013104). Fourteen of 24 (58.3%) had bridging fibrosis and 5 of 24 (20.8%) had cirrhosis at time of KP<\/jats:styled-content>. Median follow\u2010up was 8.4 years (2.08\u201315.58 years). Bilirubin normalisation within 6 months occurred in 7 of 24 (29.2%) patients and 5\u2010year NLS<\/jats:styled-content> was 45.8% (11\/24). Fourteen of 24 (58.3%) had PHT<\/jats:styled-content> and 18 of 24 (75%) patients had ascending cholangitis post\u2010KP<\/jats:styled-content>. Absence of bridging fibrosis in liver histology at KP<\/jats:styled-content> was the only factor to be significantly associated with improved 5\u2010year NLS<\/jats:styled-content>. None of the other variables examined had a significant association with either 5\u2010year NLS<\/jats:styled-content> or bilirubin normalisation by 6 months.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Five\u2010year NLS<\/jats:styled-content> in this series was 45.8%. Absence of bridging fibrosis at time of KP<\/jats:styled-content> was the only factor significantly associated with improved 5\u2010year NLS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13371","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T05:31:10Z","timestamp":1476336670000},"page":"252-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical significance of liver histology on outcomes in biliary atresia"],"prefix":"10.1111","volume":"53","author":[{"given":"Nicholas L","family":"Webb","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jiwane","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Pediatric Surgery Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Y","family":"Ooi","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Gastroenterology Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Nightinghale","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology John Hunter Children's Hospital Newcastle New South Wales Australia"},{"name":"Discipline of Paediatrics and Child Health, School of Medicine and Public Health University of Newcastle Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E","family":"Adams","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Pediatric Surgery Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Krishnan","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Gastroenterology Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-28"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60946-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318282a913"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.376"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12522"},{"key":"e_1_2_8_7_1","first-page":"71","article-title":"Management of neonatal obstructive jaundice","volume":"13","author":"Danks DM","year":"1977","journal-title":"Aust. 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