{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:02Z","timestamp":1787015702123,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Aim<\/jats:title>\n \n Whole body therapeutic hypothermia (\n TH<\/jats:styled-content>\n ) for hypoxic ischaemic encephalopathy was introduced into clinical practice in New South Wales (\n NSW<\/jats:styled-content>\n ) and Australian Capital Territory in 2007. State\u2010wide policy adopting the eligibility criteria and practice based on trial\u2010designs was published in 2009.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study was conducted by retrospectively reviewing medical records of all\n TH<\/jats:styled-content>\n infants born between 2007 and 2011 in\n NSW<\/jats:styled-content>\n and Australian Capital Territory to examine if eligibility criteria (assessed against evidence\u2010based policy directives) were met.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 207 infants received\n TH<\/jats:styled-content>\n , 104 (50%) did not meet the eligibility criteria defined in\n NSW<\/jats:styled-content>\n policy directive. Over the 5\u2010year period, the proportion of infants meeting the eligibility criteria did not change. Seventy percent of infants (73 out of 104) not meeting eligibility criteria did not fulfil the criteria for \u2018evidence of asphyxia\u2019, although half of them met \u2018moderate or severe encephalopathy criterion\u2019. Adverse events (hypotension, coagulopathy and arrhythmia), were more common in the \u2018criteria met\u2019 group than the \u2018criteria not met\u2019 group (89 vs. 71%,\n P<\/jats:italic>\n = 0.001). Similar proportions of infants had\n TH<\/jats:styled-content>\n discontinued before 72 h (criteria met: 32 (31%) vs. criteria not met: 27(26%)). Most frequent reason for early cessation was \u2018palliation\u2019 (19\/32, 59%) in criteria met and \u2018clinical improvement\u2019 (16\/27, 59%) in criteria not met group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Many\n TH<\/jats:styled-content>\n infants were treated based on clinician judgement, though not meeting the trial\u2010design policy criteria. Early\n TH<\/jats:styled-content>\n cessation (<72 h) was common. Future studies are warranted on long\u2010term neurodevelopmental outcomes for all infants receiving\n TH<\/jats:styled-content>\n particularly those with early cessation of therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.13378","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T11:07:58Z","timestamp":1476270478000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Eligibility criteria for therapeutic hypothermia: From trials to clinical practice"],"prefix":"10.1111","volume":"53","author":[{"given":"Shailender","family":"Mehta","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Neonatology Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"School of Medicine University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Joshi","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bajuk","sequence":"additional","affiliation":[{"name":"NSW Pregnancy and Newborn Services Network Sydney New South Wales Australia"},{"name":"School of Public Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Badawi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital at Westmead Sydney New South Wales Australia"},{"name":"School of Medicine University of Sydney Sydney New South Wales Australia"},{"name":"School of Medicine University of Notre Dame Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Cerebral Palsy Alliance University of Notre Dame Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Newborn Care Royal Hospital for Women Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80132-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07372.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(91)90191-5"},{"key":"e_1_2_8_5_1","first-page":"409","article-title":"No cry at birth: Global estimates of intrapartum stillbirths and intrapartum\u2010related neonatal deaths","volume":"83","author":"Lawn J","year":"2005","journal-title":"Bull. 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