{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T10:19:11Z","timestamp":1742638751992},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Biliary atresia (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) has preponderance in Asian populations with Kasai portoenterostomy (<jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content>) regarded as the first\u2010line standard of care. Yet reports from Southeast Asia remain scant. This study reviews the demographics, short\u2010 and medium\u2010term outcomes for our cohort, and evaluates prognostic factors for outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients diagnosed with <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> between January 1997 and December 2013 were included. Clinical data were obtained from medical records. Jaundice clearance was defined as total bilirubin &lt; 20 \u00b5mol\/L within 6 months after <jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content>. Two\u2010year and 5\u2010year native liver survival (<jats:styled-content style=\"fixed-case\">NLS<\/jats:styled-content>) were determined. Prognostic factors examined included gender, ethnicity, associated anomalies, age at <jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content>, post\u2010<jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content> cholangitis and clearance of jaundice within 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 58 patients studied, 31(53.4%) were male. Median age at time of <jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content> was 53 days (range: 28\u2013127). Ethnic distribution showed 32 (55.2%) Chinese, 16 (27.6%) Malays and 10 (17.2%) others. Twenty\u2010one (36.2%) patients achieved jaundice clearance by 6 months. Two\u2010year <jats:styled-content style=\"fixed-case\">NLS<\/jats:styled-content> rate was 36 out of 50 (72%), while 5\u2010year <jats:styled-content style=\"fixed-case\">NLS<\/jats:styled-content> rate was 16 out of 35 (45.7%). Only clearance of jaundice within 6 months had a significant association with <jats:styled-content style=\"fixed-case\">NLS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.006). All other factors showed no significant impact on outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our short\u2010 and medium\u2010term outcomes after <jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> are comparable with those reported by most international centres. However, prognostic factors such as age at <jats:styled-content style=\"fixed-case\">KP<\/jats:styled-content>, cholangitis episodes and associated anomalies did not show significant correlation; only clearance of jaundice within 6 months was significantly predictive of <jats:styled-content style=\"fixed-case\">NLS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13379","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T09:02:01Z","timestamp":1478595721000},"page":"412-415","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Seventeen years of Kasai portoenterostomy for biliary atresia in a single Southeast Asian paediatric centre"],"prefix":"10.1111","volume":"53","author":[{"given":"Li Wei","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan Yaw","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gita","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shireen Anne","family":"Nah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajmal","family":"Kader","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kong Boo","family":"Phua","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.09.061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181633562"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.04.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21219"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000189339.92891.64"},{"key":"e_1_2_8_7_1","first-page":"53","article-title":"Racial influence on the incidence of biliary atresia","volume":"6","author":"Wk S","year":"1974","journal-title":"Prog. 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