{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:56:52Z","timestamp":1758632212157},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IL VOLO, a no-profit Association for Rheumatic Diseases in Children, ONLUS, Padua, Italy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Aim<\/jats:title>Oligoarticular onset juvenile idiopathic arthritis (oJIA<\/jats:styled-content>) is characterised by a prevalent lower limb involvement, antinuclear antibodies (ANA<\/jats:styled-content>) positivity and high risk of anterior uveitis. As we observed that oJIA<\/jats:styled-content> patients frequently present with joint hypermobility (JH<\/jats:styled-content>), we investigated whether there was a relationship between oJIA<\/jats:styled-content> and JH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Our series consisted of children with oJIA<\/jats:styled-content>, as defined by the International League of Associations for Rheumatology criteria, for whom complete clinical data of at least 2 years\u2019 duration were available. Clinical and laboratory data, collected at disease onset and at the last follow\u2010up, included: sex, age, presence of JH<\/jats:styled-content> according to the Beighton score, disease activity, presence of uveitis, ANA<\/jats:styled-content>, treatment and outcome.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 274 oligoarticular JIA<\/jats:styled-content> patients (224 female, 50 male; mean age: 11.5) followed on average for 6.6 years, entered the study. The mean age at disease onset was 4.9 years, ANA<\/jats:styled-content> were positive in 83.9% and uveitis occurred in 20.8%. JH<\/jats:styled-content> was present in 70.8% of cases at onset, in 44.5% at the last evaluation. JH<\/jats:styled-content> was more frequent in females (73.7%) than in males (58.0%) (P<\/jats:italic> = 0.028). Uveitis was less frequent in hypermobile children both at diagnosis (17.5 vs. 28.7%, P<\/jats:italic> = 0.037) and during overall disease course (23.7 vs. 36.3%, P<\/jats:italic> = 0.034). Of 163 subjects with at least 5\u2010year follow\u2010up, the full clinical remission rate was significantly higher in JH<\/jats:styled-content> patients (50.5%) than in those without JH<\/jats:styled-content> (42.3%; P<\/jats:italic> = 0.042).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In patients with oligoarticular JIA<\/jats:styled-content>, JH<\/jats:styled-content> is more frequent than in healthy subjects, uveitis less frequent and the long\u2010term outcome better.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13450","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T11:36:40Z","timestamp":1483529800000},"page":"374-377","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Joint hypermobility and oligoarticular juvenile idiopathic arthritis: What relationship?"],"prefix":"10.1111","volume":"53","author":[{"given":"Vanessa","family":"Cecchin","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sperotto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Balzarin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Vittadello","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Zulian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"194","article-title":"Juvenile idiopathic arthritis \u2013 What the clinician needs to know","volume":"71","author":"Kahn PJ","year":"2013","journal-title":"Bull. 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