{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:34:07Z","timestamp":1782264847602,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundamental Research Grant Scheme","award":["UKM-FF-03-FRGS0038-2010"],"award-info":[{"award-number":["UKM-FF-03-FRGS0038-2010"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Aim<\/jats:title>Glucose\u20106\u2010phosphate dehydrogenase (G6PD<\/jats:styled-content>) deficiency is a recognised cause of severe neonatal hyperbilirubinaemia, and identifying which infants are at risk could optimise care and resources. In this study, we determined if G6PD<\/jats:styled-content> enzyme activity (EA<\/jats:styled-content>) and certain gene variants were associated with neonatal hyperbilirubinaemia requiring phototherapy during the first week after birth.<\/jats:p><\/jats:sec>Methods<\/jats:title>Newborn infants with G6PD<\/jats:styled-content> deficiency and a group with normal results obtained by the fluorescent spot test were selected for analyses of G6PD EA<\/jats:styled-content> and the 10 commonly encountered G6PD<\/jats:styled-content> mutations in this region, relating these with whether the infants required phototherapy before discharge from the hospital in the first week.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 222 infants with mean gestation and birth weight of 38.3\u2009\u00b1\u20091.8\u2009weeks and 3.02\u2009\u00b1\u20090.48\u2009kg, respectively, were enrolled. Of these, n<\/jats:italic>\u2009=\u2009121 were deficient with EA<\/jats:styled-content> \u22646.76\u2009U\/g Hb, and approximately half (43%) received phototherapy in the first week after birth. The mean EA<\/jats:styled-content> level was 3.7\u2009U\/g Hb. The EA<\/jats:styled-content> had good accuracy in predicting phototherapy use, with area under the receiver\u2010operating\u2010characteristic curve of 0.81\u2009\u00b1\u20090.05. Infants on phototherapy more commonly displayed World Health Organization Class II<\/jats:styled-content> mutations (<10% residual EA<\/jats:styled-content>). Logistic regression analysis showed that deficiency in EA<\/jats:styled-content> and mutation at c.1388G<\/jats:styled-content>>A (adjusted odds ratio, 1.5 and 5.7; 95% confidence interval: 1.31\u20131.76 and 1.30\u201325.0, respectively) were independent risk factors for phototherapy.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Low G6PD EA<\/jats:styled-content> (<6.76\u2009U\/g Hb) and the G6PD<\/jats:styled-content> gene variant, c.1388G<\/jats:styled-content>>A, are risk factors for the need of phototherapy in newborn infants during the first week after birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13509","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T17:14:49Z","timestamp":1491412489000},"page":"705-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glucose\u20106\u2010phosphate dehydrogenase (G6PD<\/scp>)\u2010deficient infants: Enzyme activity and gene variants as risk factors for phototherapy in the first week of life"],"prefix":"10.1111","volume":"53","author":[{"given":"Fei\u2010Liang","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Paediatrics Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azlin","family":"Ithnin","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainoon","family":"Othman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Universiti Sains Islam Malaysia Nilai Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fook\u2010Choe","family":"Cheah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.12.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80747-4"},{"key":"e_1_2_9_4_1","first-page":"405","article-title":"Semiquantitative screening test for G6PD deficiency detects severe deficiency but misses a substantial proportion of partially\u2010deficient females","volume":"34","author":"Ainoon O","year":"2003","journal-title":"Southeast Asian J. 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