{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:29:05Z","timestamp":1787063345184,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Resonance Health"},{"name":"AMRA"},{"name":"Perspectum"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2018,2]]},"abstract":"\n Aim<\/jats:title>\n \n Non\u2010alcoholic fatty liver disease (\n NAFLD<\/jats:styled-content>\n ) is the leading cause of chronic liver disease in children. The phenotype of\n NAFLD<\/jats:styled-content>\n varies widely, and non\u2010invasive predictors of disease severity are scarce and are needed to tailor clinical management.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We compared liver fibrosis by histology with proposed non\u2010invasive predictors of fibrosis, including alanine transaminase (\n ALT<\/jats:styled-content>\n ), aspartate transaminase (\n AST<\/jats:styled-content>\n ),\n AST<\/jats:styled-content>\n \/\n ALT<\/jats:styled-content>\n ratio,\n AST<\/jats:styled-content>\n to platelet ratio index, fibrosis\u20104, paediatric\n NAFLD<\/jats:styled-content>\n fibrosis index and paediatric\n NAFLD<\/jats:styled-content>\n fibrosis score.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The area under the curve of scores obtained while predicting fibrosis in children with\n NAFLD<\/jats:styled-content>\n ranged from 0.51 to 0.67.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The tested non\u2010invasive fibrosis scoring systems, some of which were originally designed for adult populations, did not adequately predict fibrosis in a paediatric cohort. Further development of risk prediction scores in children are needed for the management of paediatric patients and will likely need to be developed within a large paediatric data set in order to improve specificity and sensitivity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.13689","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:16:49Z","timestamp":1506385009000},"page":"172-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Performance of fibrosis prediction scores in paediatric non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"54","author":[{"given":"Jasmine A","family":"Jackson","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juna V","family":"Konomi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine Emory University Atlanta Georgia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine Emory University Atlanta Georgia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Krasinskas","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Atlanta Georgia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine Emory University Atlanta Georgia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Caltharp","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Atlanta Georgia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialena","family":"Mouzaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics Hospital for Sick Children, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam B","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine Emory University Atlanta Georgia United 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