{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:09:10Z","timestamp":1777421350632,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the causes, clinical presentation and neurological outcome of acute flaccid paralysis in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study in a tertiary paediatric hospital in South Africa. Data on clinical presentation, respiratory complications and long\u2010term neurological outcomes of children presenting with acute flaccid paralysis were collected. Logistic regression analysis was applied to determine predictors for the need of mechanical ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 119 patients, 99 of whom had Guillain\u2010Barr\u00e9 syndrome (GBS); 47 patients (39.5%) required mechanical ventilation. Backward logistic regression analysis revealed that bulbar dysfunction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), autonomic dysfunction (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) and upper limb paralysis (<jats:italic>P<\/jats:italic>\u2009=\u20090.038) significantly predicted the need for mechanical ventilation. EuroQol\u20105D scores of self\u2010care problems and usual activities after discharge significantly declined over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large series from Africa, GBS was the main cause of acute flaccid paralysis in children and was associated with significant morbidity. Other causes of acute flaccid paralysis mimicking <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> were not uncommon and should be excluded in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13709","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:52:40Z","timestamp":1506613960000},"page":"247-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute flaccid paralysis in South African children: Causes, respiratory complications and neurological outcome"],"prefix":"10.1111","volume":"54","author":[{"given":"Jolanda","family":"van der Pijl","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery and Pediatrics Erasmus MC\u2010Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo M","family":"Wilmshurst","sequence":"additional","affiliation":[{"name":"Division\u2009of Paediatric Neurology Red Cross War Memorial Children's Hospital  Cape Town South Africa"},{"name":"Department of Paediatrics and Child Health University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Pediatrics Erasmus MC\u2010Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Paediatric Surgery Red Cross War Memorial Children's Hospital  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Argent","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Cape Town  Cape Town South Africa"},{"name":"Division\u200aof Paediatric Critical Care, Children's Heart Disease and Paediatric Intensive Care Unit Red Cross War Memorial Children's Hospital  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Cape Town  Cape Town South Africa"},{"name":"Division of Paediatric Pulmonology Red Cross War Memorial Children's Hospital  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zampoli","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Cape Town  Cape Town South Africa"},{"name":"Division of Paediatric Pulmonology Red Cross War Memorial Children's Hospital  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0090"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2013.14.86.2032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200310000-00002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328365ad3f"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324710"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.1.74"},{"key":"e_1_2_9_8_1","first-page":"A3808","article-title":"[Imminent respiratory insufficiency in children resulting from Guillain\u2010Barre syndrome]","volume":"155","author":"Wit MC","year":"2011","journal-title":"Ned. 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