{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:03:36Z","timestamp":1790258616751,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Victorian Government's Operational Infrastructure Support Program"},{"name":"NHMRC Career Development Fellowship"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Aim<\/jats:title>Management of congenital pulmonary airway malformations (CPAM<\/jats:styled-content>) is controversial, especially for asymptomatic patients. We aim to describe the clinical manifestations and management of CPAM<\/jats:styled-content> at a tertiary paediatric hospital using a retrospective audit.<\/jats:p><\/jats:sec>Methods<\/jats:title>Infants with CPAM<\/jats:styled-content> were identified on the Fetal Diagnostic Unit database from 2007 to 2014. Information on antenatal and post\u2010natal management was collected from medical record.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010five infants with antenatally diagnosed CPAM<\/jats:styled-content> were included. Fetal CPAM<\/jats:styled-content> volume ratio (CVR<\/jats:styled-content>) was calculated from antenatal ultrasound measurement and used to categorise the infants into three groups of large (CVR<\/jats:styled-content>\u2009\u2265\u20091.6, n<\/jats:italic>\u2009=\u20098), medium (CVR<\/jats:styled-content> of 0.5\u20131.6, n<\/jats:italic>\u2009=\u200912) and small CPAM<\/jats:styled-content> (CVR<\/jats:styled-content> of \u22640.5, n<\/jats:italic>\u2009=\u200915), respectively. Ten infants (10\/35\u2009=\u200929%) were symptomatic in the neonatal period. Overall, nine infants (26%) had surgical resection, among whom eight had large or medium\u2010sized CPAM<\/jats:styled-content> lesions as defined by the antenatal CVR<\/jats:styled-content>. Three infants had neonatal emergency surgery and the remaining six had late elective surgery. Histology of eight cases showed CPAM<\/jats:styled-content>, but one case showed congenital lobar emphysema. Criteria for surgery varied and included persistent symptoms after birth, complications during childhood and persistently abnormal chest X\u2010ray. Most asymptomatic infants with CPAM<\/jats:styled-content> were safely managed using a conservative approach, with no significant increase in late symptoms or complications.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Conservative management of CPAM<\/jats:styled-content> may be considered for infants\/children who remain asymptomatic, especially those with a small lesion. For large and medium\u2010sized CPAM<\/jats:styled-content>, delineation using computed tomography is required, and surgery may be beneficial to prevent late symptoms and the risk of emergency surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13727","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:53:57Z","timestamp":1506614037000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Conservative post\u2010natal management of antenatally diagnosed congenital pulmonary airway malformations"],"prefix":"10.1111","volume":"54","author":[{"given":"Allya V","family":"Makhijani","sequence":"first","affiliation":[{"name":"Monash Newborn Monash Medical Centre Clayton Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Y","family":"Wong","sequence":"additional","affiliation":[{"name":"Monash Newborn Monash Medical Centre Clayton Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053905"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30832"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.118"},{"key":"e_1_2_9_5_1","first-page":"22","article-title":"Antenatally diagnosed congenital cystic adenomatoid malformations (CCAM): Research review","volume":"6","author":"Di Prima F","year":"2012","journal-title":"J. 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