{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:39:07Z","timestamp":1771612747735,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Aim<\/jats:title>The human parechovirus (HPeV<\/jats:styled-content>) is an increasingly recognised cause of sepsis and central nervous system infection in young infants for which there are limited long\u2010term outcome data. We aimed to assess neurodevelopmental outcome and quality of life in infants following hospitalised HPeV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>Methods<\/jats:title>This cohort study was a 12\u2010month follow\u2010up of infants who were hospitalised with confirmed HPeV<\/jats:styled-content> infection at the Sydney Children's Hospitals Network during an outbreak in Sydney in 2013. Telephone interviews were conducted with parents\/guardians. We administered standardised questionnaires, including: Ages and Stages Questionnaire (ASQ<\/jats:styled-content>), Liverpool Outcome Score\u2010follow\u2010up, Pediatric Quality of Life Inventory(PedsQL<\/jats:styled-content>) Infant scales and Short\u2010Form health survey (SF<\/jats:styled-content>\u201012).<\/jats:p><\/jats:sec>Results<\/jats:title>We followed up 46 of 79 infants (58%) aged between 12 and 16 months who had been hospitalised with HPeV<\/jats:styled-content> infection; 19% showed significant concern in developmental attainment (ASQ3<\/jats:styled-content> score <2 standard deviation below population mean), and 50% showed some concern (<1 standard deviation below mean). ASQ3<\/jats:styled-content> developmental outcome was associated with the presence of neurodevelopmental sequelae (lower total Liverpool Outcome Score) and poorer health\u2010related quality of life (HRQOL<\/jats:styled-content>) in physical functioning (PedsQL<\/jats:styled-content> physical component score), but not overall HRQOL<\/jats:styled-content> (total PedsQL<\/jats:styled-content> score) or parental HRQOL<\/jats:styled-content> (SF<\/jats:styled-content>\u201012 scores). No significant associations were identified between clinical or laboratory features during acute hospitalisation and adverse outcome on ASQ3<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A high proportion of infants show developmental concern at 12\u2010month follow\u2010up post\u2010hospitalisation with HPeV<\/jats:styled-content> infection. Clinical features during hospitalisation were not associated with adverse outcomes at 12 months. These results suggest that careful follow\u2010up of young infants hospitalised with HPeV<\/jats:styled-content> disease may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13728","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:54:14Z","timestamp":1506614054000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["High prevalence of developmental concern amongst infants at 12 months following hospitalised parechovirus infection"],"prefix":"10.1111","volume":"54","author":[{"given":"Philip N","family":"Britton","sequence":"first","affiliation":[{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity University of Sydney Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases and Microbiology Children's Hospital at Westmead Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulam","family":"Khandaker","sequence":"additional","affiliation":[{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameneh","family":"Khatami","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Microbiology Children's Hospital at Westmead Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzy","family":"Teutsch","sequence":"additional","affiliation":[{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan J","family":"McMullan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl A","family":"Jones","sequence":"additional","affiliation":[{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity University of Sydney Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases and Microbiology Children's Hospital at Westmead Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/498905"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000456"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000401"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000112"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(14)70023-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318194596a"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/599094"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.07.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/INF.0b013e318276b328","article-title":"Characteristics of young infants in whom human parechovirus, enterovirus or neither were detected in cerebrospinal fluid during sepsis evaluations","volume":"32","author":"Sharp J","year":"2013","journal-title":"Pediatr. 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