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On behalf of the Australasian Paediatric Endocrine Group, this evidence\u2010based consensus guideline presents recommendations and discusses the graded evidence (using the\n                    <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content>\n                    system) for these recommendations. Primary bone fragility disorders such as osteogenesis imperfecta are considered separately from osteoporosis secondary to other clinical conditions (such as cerebral palsy, Duchenne muscular dystrophy). The use of bisphosphonates in non\u2010fragility conditions, such as fibrous dysplasia, avascular necrosis, bone cysts and hypercalcaemia, is also discussed. While these guidelines provide an evidence\u2010based approach where possible, further research is required in all clinical applications in order to strengthen the recommendations made.\n                  <\/jats:p>","DOI":"10.1111\/jpc.13768","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T01:45:12Z","timestamp":1520214312000},"page":"223-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Consensus guidelines on the use of bisphosphonate therapy in children and adolescents"],"prefix":"10.1111","volume":"54","author":[{"given":"Peter J","family":"Simm","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria 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