{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:13:47Z","timestamp":1792214027075,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Chylothorax is a rare but life\u2010threatening condition in newborns. Octreotide, a somatostatin analogue, is widely used as a therapeutic option in neonates with congenital and acquired chylothorax, but its therapeutic role has not been clarified yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review to assess the efficacy and safety of octreotide in the treatment of congenital and acquired chylothorax in newborns. Comprehensive research, updated till 31 October 2017, was performed by searching in PubMed, MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) databases using the MeSH terms \u2018octreotide\u2019 and \u2018chylothorax\u2019. Both term and preterm newborns with congenital or acquired chylothorax treated with octreotide within the 30th day of life were included. Octreotide treatment was considered effective if a progressive reduction\/ceasing in drained chylous effusion occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 39 articles were included. Octreotide was effective in 47% of patients, with a slight but not significant difference between congenital (30\/57; 53.3%) and acquired (9\/27; 33.3%) chylothorax (<jats:italic>P<\/jats:italic> = 0.10). Marked variation in octreotide regimen was observed. The most common therapeutic scheme was intravenous infusion at a starting dose of 1 \u03bcg\/kg\/h, gradually increasing to 10 \u03bcg\/kg\/h according to the therapeutic response. Side effects were reported in 12 of 84 patients (14.3%). Only case reports were included in this review due to the lack of randomised controlled trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Octreotide is a relatively effective and safe treatment option in neonates with chylothorax, especially for the congenital forms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13889","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T22:30:24Z","timestamp":1522449024000},"page":"840-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Octreotide for congenital and acquired chylothorax in newborns: A systematic review"],"prefix":"10.1111","volume":"54","author":[{"given":"Carlo","family":"Bellini","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department of Mother and Child Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Cabano","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department of Mother and Child Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department of Mother and Child Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bellini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department of Mother and Child Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G","family":"Calevo","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Committees Unit Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gandullia","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca A","family":"Ramenghi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department of Mother and Child Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"75","article-title":"Dynamics of pleural effusion and chylothorax in the fetus and newborn: Role of the lymphatic system","volume":"46","author":"Bellini C","year":"2013","journal-title":"Lymphology"},{"key":"e_1_2_8_3_1","first-page":"91","article-title":"Congenital fetal and neonatal visceral chylous effusions: Neonatal chylothorax and chylous ascites revisited. 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