{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:07:23Z","timestamp":1792811243649,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C\u2010reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline\/PubMed was searched using the terms \u2018procalcitonin\u2019, \u2018C\u2010reactive protein\u2019, \u2018bacterial infection\u2019 and \u2018neonatal sepsis\u2019. Three systematic reviews relevant to the clinical question were identified and the key article selected for critical appraisal was the systematic review by Yu <jats:italic>et al<\/jats:italic>. (2010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The appraised literature concludes that procalcitonin has moderate accuracy in diagnosing neonatal sepsis, but suggests it should be considered only within the context of other clinical parameters and other relevant investigations. The studies included in the systematic review were of variable quality, showed considerable heterogeneity in their methods and evidence of possible publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further research is required before definitive recommendations can be made about the utility of procalcitonin compared with CRP as a diagnostic marker for neonatal sepsis and bacterial infection in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13931","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T05:57:09Z","timestamp":1524031029000},"page":"695-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Procalcitonin and C\u2010reactive protein as biomarkers for neonatal bacterial infection"],"prefix":"10.1111","volume":"54","author":[{"given":"Ashfaque F","family":"Quadir","sequence":"first","affiliation":[{"name":"Discipline of Child and Adolescent Sydney Medical School, University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases and Microbiology Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N","family":"Britton","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Sydney Medical School, University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases and Microbiology Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Marie Bashir Institute of Infectious Diseases and Biosecurity Institute University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.022863"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.09.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.00997.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.064188"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.025171"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/S0021-9258(19)69685-7","article-title":"Procalcitonin is a glycoprotein","volume":"256","author":"Jacobs JW","year":"1981","journal-title":"J. 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