{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:40:03Z","timestamp":1782531603938,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Recent evidence is emerging indicating long\u2010term effects in infants born after an episode of preterm labour (PTL), even if birth is at term. This population\u2010based study compared long\u2010term rates of outcomes and health\u2010care utilisation (HCU) in children born following spontaneous preterm labour, irrespective of gestational age at delivery or of an uncomplicated pregnancy (SPTLu), with children born following full\u2010term labour (FTL), overall stratified by comorbidity status and assessed using a composite morbidity measure (CM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective data on mother\u2013neonate pairs were collected from a patient\u2010linked dataset from the Netherlands Perinatal Registry and the PHARMO Database Network. Children born between 2000 and 2010 were followed until 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of pregnancies in 134 006 mother\u2013neonate pairs, 122 894 (92%) pregnancies resulted in FTL, and 11 112 (8%) resulted in PTL. Of the PTL pregnancies, 6599 (59%) were SPTLu. Mean follow\u2010up after birth was 6.6\u20136.7 years. Children from SPTLu pregnancies were at increased risk of neurodevelopmental and respiratory conditions compared with those from FTL pregnancies. In children from SPTLu pregnancies, the presence of the CM was associated with an increased risk of respiratory conditions and failure to thrive. Post\u2010natal hospitalisations (incidence rate (IR) per 100 patient\u2010years: 18.1 vs. 11.7) and specialist referrals (IR per 1000 patient\u2010years: 290.6 vs. 184.5) occurred significantly more frequently in children from SPTLu versus FTL pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increased risk of morbidities and HCU in children born following SPTLu pregnancy in this population\u2010based setting reinforces the need for safe interventions that can effectively halt labour and lead to an improvement in childhood outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14225","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T03:07:43Z","timestamp":1538795263000},"page":"446-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased risk of morbidities and health\u2010care utilisation in children born following preterm labour compared with full\u2010term labour: A population\u2010based study"],"prefix":"10.1111","volume":"55","author":[{"given":"Eline","family":"Houben","sequence":"first","affiliation":[{"name":"PHARMO Institute for Drug Outcomes Research  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Smits","sequence":"additional","affiliation":[{"name":"PHARMO Institute for Drug Outcomes Research  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Real World Evidence (Epidemiology)  Middlesex United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby K","family":"Black","sequence":"additional","affiliation":[{"name":"Value Evidence and Outcomes  Research Triangle Park, North Carolina United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene D","family":"Bezemer","sequence":"additional","affiliation":[{"name":"PHARMO Institute for Drug Outcomes Research  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernie JA","family":"Penning\u2010van Beest","sequence":"additional","affiliation":[{"name":"PHARMO Institute for Drug Outcomes Research  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.10.638"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.07.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.12.030"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2016.01.004"},{"key":"e_1_2_7_8_1","unstructured":"ClinicalTrials.gov.A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor (NEWBORN\u20101). 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