{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:27:11Z","timestamp":1789680431470,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Approximately 6\u20139% pregnancies are affected by fetal growth restriction (FGR). Placental alterations related to utero\u2010placental insufficiency in FGR may induce placental vascular remodelling to the detriment of the fetus. The objective of this article was to study histopathological features of placentae in a cohort of preterm growth\u2010restricted infants in comparison to a cohort of preterm appropriately grown infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cohort of 40 preterm infants of 28\u201332\u2009weeks' gestation, placental histopathology was evaluated by a histopathologist, who was blinded to the identity of the grouping. Twenty infants had FGR, while 20 were appropriate for gestational age (AGA). Predefined histopathological characteristics were assessed based on the Amsterdam Placental Workshop Group Consensus Statement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gestational age and birthweight of the FGR and AGA cohorts were 29.8\u2009\u00b1\u20091.3 versus 30\u2009\u00b1\u20090.9\u2009weeks, <jats:italic>P<\/jats:italic>\u2009=\u20090.78 and 923\u2009\u00b1\u2009168 versus 1403\u2009\u00b1\u2009237\u2009g, &lt;0.001, respectively. Maternal vascular malperfusion, accelerated villous maturation and fetal vascular malperfusion were features that were significantly more common in FGR placentae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the results of the present study, specific placental histopathological changes may be present in FGR placentae, which may reflect the effects of utero\u2010placental insufficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14251","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T03:13:03Z","timestamp":1538795583000},"page":"582-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Placental histopathology in preterm fetal growth restriction"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-7529","authenticated-orcid":false,"given":"Arvind","family":"Sehgal","sequence":"first","affiliation":[{"name":"Monash Newborn Monash Children's Hospital  Melbourne Victoria Australia"},{"name":"Department of Pediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E","family":"Dahlstrom","sequence":"additional","affiliation":[{"name":"Anatomical Pathology ACT Pathology and Australian National University Medical School  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth J","family":"Allison","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L","family":"Miller","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme R","family":"Polglase","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.11.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2004.03.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4084"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2004.03.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000181381.82856.23"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2784"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(13)70013-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002264"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.631"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10508-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02068-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1978.58.2.397"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000048341.52293.7C"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994718"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2017.135"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270495"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.06.375"},{"key":"e_1_2_7_24_1","first-page":"533","article-title":"An immunologic basis for placental insufficiency in fetal growth restriction","volume":"29","author":"Greer LG","year":"2012","journal-title":"Am. 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