{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:39Z","timestamp":1787015679821,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the prevalence, types and indications for fluid bolus therapy in neonates with haemodynamic compromise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a pragmatic, international, multicentre observational study in neonatal units across Australasia, Europe and North America with a predefined study period of 10\u201315 study days per participating neonatal unit between December 2015 and March 2017. Infants \u226428\u2009days of age who received a fluid bolus for the management of haemodynamic compromise (\u226510 mL\/kg given at \u22646 h) were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 163 neonates received a bolus over 8479 eligible patient days in 41 neonatal units. Prevalence of fluid bolus therapy varied between centres from 0 to 28.6% of admitted neonates per day, with a pooled prevalence rate of 1.5% (95% confidence interval 1.1\u20131.9%). The most common fluid used was 0.9% sodium chloride (129\/163; 79%), and the volume of fluid administered was most commonly 10 mL\/kg (115\/163; 71%) over a median of 30 min (interquartile range 20\u201360). The most frequent indications were hypotension (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956; 34%), poor perfusion (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920; 12%) and metabolic acidosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920; 12%). Minimal or no clinical improvement was reported by clinicians in 66 of 163 cases (40%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Wide international variations in types, indications and effects of fluid bolus administration in haemodynamically compromised neonates suggest uncertainty in the risk\u2013benefit profile. This is likely to reflect the lack of robust evidence to support the efficacy of different fluid types, doses and appropriate indications. Together, these highlight a need for further clinically relevant studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.14260","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T21:34:01Z","timestamp":1539725641000},"page":"632-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["International, multicentre, observational study of fluid bolus therapy in neonates"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-5676","authenticated-orcid":false,"given":"Amy K","family":"Keir","sequence":"first","affiliation":[{"name":"Robinson Research Institute, Adelaide Medical School, University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Neonatal Medicine Women's and Children's Hospital  Adelaide South Australia Australia"},{"name":"Healthy Mothers, Babies and Children South Australian Medical and Research Institute  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Karam","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Geneva University Hospital  Geneva Switzerland"},{"name":"Division of Pediatric Critical Care Medicine Children's Hospital of Richmond at VCU, Virginia Commonwealth University  Richmond Virginia United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Hodyl","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, Adelaide Medical School, University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Neonatal Medicine Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Stark","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, Adelaide Medical School, University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Neonatal Medicine Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen G","family":"Liley","sequence":"additional","affiliation":[{"name":"Department of Neonatology Mater Mothers' Hospital, Mater Research  Brisbane Queensland Australia"},{"name":"Faculty of Clinical Medicine and Mater Research Institute University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakesh S","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J","family":"Stanworth","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant and Department of Haematology Oxford University Hospitals NHS Foundation Trust  Oxford United Kingdom"},{"name":"Radcliffe Department of Medicine University of Oxford  Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the NeoBolus Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002055.pub2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.057844"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309182"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80642-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2003.00474.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v049.i05"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2872"},{"key":"e_1_2_7_10_1","article-title":"Post transfusion lung injury in the neonatal population","author":"Rashid N","year":"2012","journal-title":"J. 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