{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:02Z","timestamp":1788498842530,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Paediatric vitamin D (25\u2010hydroxyvitamin D (25OHD)) deficiency can lead to nutritional rickets and extra\u2010skeletal complications. Compliance with daily therapy can be difficult, making high\u2010dose, short\u2010term vitamin D (stoss) therapy attractive to correct vitamin D deficiency. We compared the effectiveness and safety of standard versus stoss therapy in treating childhood 25OHD deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged 2\u201316\u2009years with 25OHD &lt;50\u2009nmol\/L were randomised to either standard (5000\u2009IU daily for 80\u2009days) or stoss (100\u2009000\u2009IU weekly for 4 weeks) cholecalciferol. Participants underwent an evaluation of effectiveness and safety. The 25OHD level, random spot calcium: creatinine ratio (Ca:Cr) and compliance were measured at 12\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 151 children were enrolled in the study (68 standard and 83 stoss), median age 9 years (inter\u2010quartile range (IQR): 6\u201312\u2009years). Baseline 25OHD levels were 26\u2009nmol\/L (IQR: 19\u201335\u2009nmol\/L) and 32\u2009nmol\/L (IQR: 24\u201339\u2009nmol\/L) in the standard and stoss groups, respectively. At 12\u2009weeks, the median 25OHD level was significantly greater in the standard versus stoss group (81 vs. 67\u2009nmol\/L; <jats:italic>P<\/jats:italic> = 0.005); however, &gt;80% of participants in both groups achieved sufficiency (25OHD\u2009&gt;\u200950\u2009nmol\/L) and had normal urinary Ca:Cr, with no significant difference seen between groups. Compliance was similar in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to stoss, standard therapy achieved higher 25OHD levels at 12\u2009weeks; however, in both groups, there was a similar proportion of participants who achieved 25OHD sufficiency, with no evidence of toxicity. Unlike other studies, simplifying the treatment regimen did not improve compliance. These results support stoss therapy as an effective and safe alternative therapy for the treatment of paediatric vitamin D deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14497","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:30:36Z","timestamp":1559050236000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Safety and effectiveness of stoss therapy in children with vitamin D deficiency"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-7859","authenticated-orcid":false,"given":"Paul","family":"Tannous","sequence":"first","affiliation":[{"name":"Department of General Paediatrics Sydney Children's Hospitals Network  Sydney New South Wales Australia"},{"name":"School of Medicine Sydney, NSW University of Notre Dame  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Fiscaletti","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead Sydney Children's Hospitals Network  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Immunisation Research, The Children's Hospital at Westmead Sydney Children's Hospitals Network  Sydney New South Wales Australia"},{"name":"Children's Hospital Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4900-1277","authenticated-orcid":false,"given":"Hasantha","family":"Gunasekera","sequence":"additional","affiliation":[{"name":"Children's Hospital Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Zurynski","sequence":"additional","affiliation":[{"name":"Health Systems Sustainability, Australian Institute of Health Innovation Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Biggin","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Children's Hospital Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Kilo","sequence":"additional","affiliation":[{"name":"Department of Haematology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Hayes","sequence":"additional","affiliation":[{"name":"Scientific Advisory Board FIT\u2010BIOCeuticals  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Munns","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Children's Hospital Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00558.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-18.4.277"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0442"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3054"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2002.tb04702.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10662"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11592"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0254"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1894"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83303-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063214"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.4.e46"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Disorders of calcium and phosphate metabolism in childhood and adolescence","volume":"20","author":"Harrison HE","year":"1979","journal-title":"Major Probl. Clin. Pediatr."},{"key":"e_1_2_8_16_1","unstructured":"Bioceuticals.BioCeuticals Vitamin D3 Range: Accurate Dose Low Risk Contamination and High\u2010Strength. Sydney: BioCeuticals; 2013. Available from:https:\/\/www.bioceuticals.com.au\/mobile\/article\/publi\/bioceuticals\u2010vitamin\u2010d3\u2010range\u2010accurate\u2010dose\u2010low\u2010risk\u2010contamination\u2010and\u2010high\u2010strength[accessed 15 November 2018]."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2175"},{"key":"e_1_2_8_18_1","volume-title":"Notes on Paediatric Clinical Biochemistry: A Case Oriented Approach","author":"Coakley J."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.06.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2111"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02490.x"},{"key":"e_1_2_8_22_1","first-page":"497","article-title":"Treatment of vitamin D deficiency within a large integrated health care delivery system","volume":"18","author":"Stratton\u2010Loeffler MJ","year":"2012","journal-title":"J. Manag. Care Pharm."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.04.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2003.00344.x"},{"key":"e_1_2_8_25_1","first-page":"355","article-title":"Hiding from the sun \u2013 Vitamin D deficiency in refugees","volume":"36","author":"Benson J","year":"2007","journal-title":"Aust. Fam. Physician"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022179"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000823"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2011-0368"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1989.11748616"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000355"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443136"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2530"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2003.16.8.1105"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-014-0399-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.204"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.14497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:12:35Z","timestamp":1693973555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.14497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/jpc.14497"],"URL":"https:\/\/doi.org\/10.1111\/jpc.14497","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,28]]},"assertion":[{"value":"2018-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}