{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:53Z","timestamp":1747186673236,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Sporotrichosis is a dermatomycosis caused by the dimorphic fungus, <jats:italic>Sporothrix schenckii<\/jats:italic>, with various outbreaks across Australia attributed to mouldy hay. Our objective was to investigate the clinical presentation and management of cutaneous sporotrichosis in a paediatric population of Western Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case review was performed for <jats:italic>S. schenckii<\/jats:italic> infections in children below 18\u2009years, between January 2000 and November 2017. Cases were identified from the state\u2010wide laboratory database and additional clinical data obtained from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two cases of microbiologically proven <jats:italic>S. schenckii<\/jats:italic> infection were identified, mostly from rural areas (<jats:italic>n<\/jats:italic> =\u200920, 63%). Complete clinical data were available for 11 cases (34%). The most common risk factors were exposure to farm animals and hay, arthropod bites and outdoor activities. The median duration from symptom onset to correct diagnosis was 6\u2009weeks (interquartile range: 4\u20137\u2009weeks). Most cases were initially treated with multiple, broad\u2010spectrum antibacterial agents (<jats:italic>n<\/jats:italic> =\u20097, 64%). Targeted therapy (itraconazole) was used in all cases once the diagnosis was made, with a median treatment duration of 5\u2009months (interquartile range: 4\u20136 months). Morbidity included scarring (<jats:italic>n<\/jats:italic> =\u20094, 31%), itraconazole associated diarrhoea (<jats:italic>n<\/jats:italic> =\u20091, 8%) and mild hepatotoxicity (<jats:italic>n<\/jats:italic> =\u20091, 8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Summarising the clinical experience of these cases is a useful guide for clinical recognition and may serve to shorten the interval between onset and diagnosis, and avoid the need for antibacterial therapy. These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting, leading to timely diagnosis and appropriate treatment with antifungal agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14639","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T10:06:33Z","timestamp":1571133993000},"page":"408-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spotting sporotrichosis skin infection: The first Australian paediatric case series"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-0776","authenticated-orcid":false,"given":"Anna","family":"Schauer","sequence":"first","affiliation":[{"name":"Department of Dermatology Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita J","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Division of Medicine University of Western Australia  Perth Western Australia Australia"},{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases Telethon Kids Institute  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris C","family":"Blyth","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Division of Medicine University of Western Australia  Perth Western Australia Australia"},{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases Telethon Kids Institute  Perth Western Australia Australia"},{"name":"Department of Microbiology PathWest Laboratory Medicine WA  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha C","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Division of Medicine University of Western Australia  Perth Western Australia Australia"},{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases Telethon Kids Institute  Perth Western Australia Australia"},{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1308.061462"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1338-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00452.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1998.tb01239.x"},{"key":"e_1_2_7_6_1","first-page":"217","article-title":"Sporotrichosis outbreak and mouldy hay in NSW","volume":"44","author":"Dhingra D","year":"2015","journal-title":"Aust. Fam. Physician"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1951.tb01418.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0456"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.14639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.14639","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:53:03Z","timestamp":1694062383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.14639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/jpc.14639"],"URL":"https:\/\/doi.org\/10.1111\/jpc.14639","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"type":"print","value":"1034-4810"},{"type":"electronic","value":"1440-1754"}],"subject":[],"published":{"date-parts":[[2019,10,15]]},"assertion":[{"value":"2019-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}