{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:03:15Z","timestamp":1773885795069,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>It is challenging to evaluate reproductive potential during childhood. These challenges necessitate the use of invasive dynamic tests. Although the anti\u2010Mullerian hormone (AMH) is a reliable biomarker in evaluating testicular function, especially in the pre\u2010pubertal period, there are uncertainties concerning its use in a clinical setting.<\/jats:p><jats:p>This study is focused on comparing the AMH and human chorionic gonadotropin (hCG) test in boys with hypogonadism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 160 boys aged between 0 and 18\u2009years who presented with complaints associated with hypogonadism were prospectively enrolled in the study. All children were assigned to the following five groups: gonadal disorders (<jats:italic>n<\/jats:italic>= 34), androgen synthesis and end organ effect disorder (<jats:italic>n<\/jats:italic>= 48), isolated genital malformation disorders (<jats:italic>n<\/jats:italic>= 57), hypogonadotropic hypogonadism (<jats:italic>n<\/jats:italic>= 15) and constitutional delayed puberty (<jats:italic>n<\/jats:italic>= 6). All children underwent a short 3\u2010day hCG test (1500\u2009U\/m<jats:sup>2<\/jats:sup>\/day). The concordance and correlation were evaluated between the hCG test and AMH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All groups exhibited a strong correlation (<jats:italic>r<\/jats:italic><jats:sub>160<\/jats:sub>= 0.689) and strong concordance (Kappa coefficient<jats:sub>160<\/jats:sub>= 0.7) between the AMH and hCG test. Values of AMH higher than 32.7 pmol\/L and hCG responses higher than 86\u2009pmol\/L were significant as indicative markers of functional testicular tissue presence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has shown that there is a strong correlation between the AMH and short\u2010term hCG test and that values of AMH higher than 32.7 pmol\/L and stimulated testosterone higher than 86 pmol\/L can be used as indicators of functionally sufficient testicular tissue. These results indicate that AMH value can be used as a reliable and useful biomarker in the evaluation of the testicular function in 46 XY hypogonadism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14643","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T22:54:23Z","timestamp":1571180063000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of anti\u2010Mullerian hormone with humanchorionic gonadotropin test in the evaluation of testicular function of children with 46 XY male hypogonadism: Use of anti\u2010Mullerian hormone as abiomarker"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-3568","authenticated-orcid":false,"given":"Murat","family":"Karaoglan","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine Gaziantep University Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/128907"},{"key":"e_1_2_7_3_1","first-page":"488","article-title":"Consensus statement on management of intersex disorders","volume":"118","author":"Lee PA","year":"2006","journal-title":"Arch. 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