{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:46:50Z","timestamp":1791377210307,"version":"4.3.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Vanishing gastroschisis describes the <jats:italic>in utero<\/jats:italic> spontaneous closure of the periumbilical defect. It is usually associated with intestinal loss due to ischaemia, necrosis and atresia. This comparative study aims to investigate the spectrum of pathology, antenatal ultrasound characteristics and post\u2010natal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our tertiary centre provides antenatal and post\u2010natal care of major congenital anomalies for a population of 1.6 million. Medical records were retrospectively evaluated for all cases of vanishing gastroschisis from May 2014 to May 2015. Cases of normal variant gastroschisis born during the same period were used for comparison. Maximum antenatael bowel diameter measurements were compared using the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six infants with vanishing gastroschisis were born during the study period, representing 50% of all live\u2010born gastroschisis. Antenatal ultrasound showed progressively increasing intra\u2010abdominal bowel dilatation, with antenatal intra\u2010abdominal bowel diameter significantly greater in vanishing, than normal, variant gastroschisis (23.2 vs. 4.1\u2009mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The classification of vanishing gastroschisis severity comprised two type I, three type II and one type III cases. Complete midgut atresia affected three infants, leading to overall mortality of 50% for the vanishing gastroschisis group versus 0% in the normal variant group (<jats:italic>P<\/jats:italic> =\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vanishing gastroschisis is a severe, often catastrophic variant of gastroschisis. Aetiological factors contributing to the recent high incidence of this rare complication in our population of newborns remain unknown, prompting secondary prevention strategies to salvage the midgut. We propose closer antenatal surveillance for fetuses with intra\u2010abdominal bowel dilatation &gt;10\u2009mm to prompt consideration of earlier delivery to improve morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14644","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T22:54:28Z","timestamp":1571180068000},"page":"420-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional cluster of vanishing gastroschisis: A comparative study of antenatal and post\u2010natal outcomes"],"prefix":"10.1111","volume":"56","author":[{"given":"Jeremy","family":"Granger","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-502X","authenticated-orcid":false,"given":"Montgommery","family":"Do\u2010Wyeld","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P","family":"Cundy","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Galek","sequence":"additional","affiliation":[{"name":"Division of Medical Imaging Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Neonatology Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L","family":"Cord\u2010Udy","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"72","article-title":"A proposed classification for the spectrum of vanishing gastroschisis","volume":"23","author":"Kumar T","year":"2013","journal-title":"Eur. 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