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Increased knowledge regarding the pathogenesis, improved diagnostic techniques and increased awareness over the years have transformed our understanding of CD such that it is no longer a rare enteropathy, but rather a common multisystem disorder which affects individuals of all ages and results in wide\u2010ranging clinical manifestations. Only a minority of children now present with the classical clinical picture of profound diarrhoea and malnutrition. An increasing number of children with CD present with either mild, non\u2010specific gastrointestinal symptoms or extra\u2010intestinal manifestations or even be asymptomatic, as in many screening\u2010detected children. Knowledge about these diverse manifestations and a high index of suspicion is essential so that appropriate investigations can be undertaken, diagnosis established and treatment initiated. Although traditionally small bowel biopsy is considered essential for the diagnosis, recent guidelines from various professional bodies have paved the way to a biopsy\u2010free diagnosis in a subset of symptomatic children. Life long, strict gluten\u2010free diet still remains the only effective treatment at present, although several novel therapeutic agents are in various phases of clinical trials.<\/jats:p>","DOI":"10.1111\/jpc.14674","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:35:13Z","timestamp":1605573313000},"page":"1685-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Coeliac disease in childhood: An overview"],"prefix":"10.1111","volume":"56","author":[{"given":"Jonathan","family":"Bishop","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Starship Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5422-7284","authenticated-orcid":false,"given":"Madhur","family":"Ravikumara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"\"On the C\u0153liac Affection\". 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