{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:32:49Z","timestamp":1762867969313,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>The late outcome in 55 children with infection\u2010mediated haemolytic uremic syndrome (Shiga Toxin E Coli (STEC)\u2010HUS and pneumococcal HUS) observed in 1979\u20131995 was followed up 23\u2009years after disease onset. Of these, two were later confirmed to have atypical HUS (aHUS). Furthermore, of this population, five children had impaired kidney function at 3\u2010months follow\u2010up, which continued to deteriorate. These children had significant oliguria\/anuria and hypertension during their illness requiring early dialysis and antihypertensive therapy. At 23\u2009years post\u2010disease onset, all five (100%) of these children have developed end\u2010stage kidney disease or chronic kidney disease. Eculizumab is a monoclonal antibody that binds with high affinity to the C5 protein of the complement pathway, a major component of the pathophysiology of infection\u2010mediated HUS. There are no long\u2010term randomised controlled trials in the literature to support its use in such cases. Our 23\u2010year follow\u2010up of a population of severely affected children with infection\u2010mediated HUS demonstrates a high percentage of chronic kidney disease and end\u2010stage kidney disease (19%). Randomised controlled trials with eculizumab are now being conducted in this affected cohort.<\/jats:p>","DOI":"10.1111\/jpc.14685","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T15:28:37Z","timestamp":1573313317000},"page":"577-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Follow\u2010up of children with infection\u2010associated haemolytic uraemic syndrome 1979\u20131995: Would eculizumab have improved prognosis?"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-9996","authenticated-orcid":false,"given":"Melanie","family":"Aldridge","sequence":"first","affiliation":[{"name":"Department of Nephrology Queensland Children's Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland 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