{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:38:54Z","timestamp":1789331934906,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the risk of ocular complications of sildenafil therapy in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case review of neonates with persistent pulmonary hypertension of the newborn who received sildenafil therapy between 2010 and 2015 in a single, tertiary surgical neonatal intensive care unit in Australia. Ophthalmic examination findings in the neonatal intensive care unit and follow\u2010up were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven neonates with persistent pulmonary hypertension of the newborn received sildenafil. The median gestational age (GA) was 38\u2009weeks (range 24\u201341\u2009weeks), and median birthweight was 2690\u2009g (range 454\u20134270\u2009g). Ophthalmic review was undertaken in 23 neonates, and 16 neonates were term or near\u2010term infants (GA 31\u201340\u2009weeks). All of them had a normal initial ophthalmic examination; one child was later diagnosed with hypermetropia and another with infantile esotropia. Amongst the seven premature infants (GA 24\u201330\u2009weeks), three had retinopathy of prematurity (ROP) diagnosed at the first ophthalmic review and the other four had normal initial examinations. Two patients later developed ROP, one of whom was also diagnosed with congenital motor nystagmus. All five patients diagnosed with ROP were extremely preterm (&lt;28\u2009weeks) with low birthweight (454\u2013635\u2009g).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no short\u2010term complications attributable to sildenafil therapy identified in term or near\u2010term neonates (GA \u226531\u2009weeks). This cohort of neonates does not typically undergo ophthalmic review as part of the ROP screening protocol in our institution. Routine ophthalmic review of neonates on sildenafil therapy, who are not at risk of ROP, is therefore unlikely to be warranted. Further research is required to clarify the relationship between sildenafil and ROP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14766","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T09:49:57Z","timestamp":1578563397000},"page":"884-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ophthalmic findings in neonates receiving sildenafil"],"prefix":"10.1111","volume":"56","author":[{"given":"Hamish P","family":"Dunn","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Department of Ophthalmology Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Department of Ophthalmology University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-1697","authenticated-orcid":false,"given":"Leah N","family":"Kim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Sydney  Sydney New South Wales Australia"},{"name":"Grace Centre for Newborn Intensive Care Children's Hospital Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Sydney  Sydney New South Wales Australia"},{"name":"Grace Centre for Newborn Intensive Care Children's Hospital Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Lock","sequence":"additional","affiliation":[{"name":"Children's Hospital Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Children's Hospital Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000077"},{"key":"e_1_2_8_3_1","first-page":"CD005494","article-title":"Sildenafil for pulmonary hypertension in neonates","author":"Shah PS","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2009.12.161"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-204262"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12726"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-007-0053-1"},{"key":"e_1_2_8_8_1","first-page":"S155","article-title":"Possible role of sildenafil citrate in the recurrence of neovascularization in laser\u2010regressed aggressive posterior ROP","volume":"53","author":"Jayadev C","year":"2016","journal-title":"Indian Pediatr."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.021956"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.84"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.126"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3352-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e554"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.06.023"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000299"},{"key":"e_1_2_8_17_1","first-page":"595","article-title":"Non\u2010arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction","volume":"95","author":"McGwin G","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31815ec2c8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02305.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.054023"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.14766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.14766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:40:40Z","timestamp":1693615240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.14766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jpc.14766"],"URL":"https:\/\/doi.org\/10.1111\/jpc.14766","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]},"assertion":[{"value":"2019-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}