{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:27:03Z","timestamp":1790818023792,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1081736"],"award-info":[{"award-number":["GNT1081736"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1058560"],"award-info":[{"award-number":["GNT1058560"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014607","name":"Royal Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002076","name":"Emergency Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Nasal high\u2010flow oxygen therapy is increasingly used in infants for supportive respiratory therapy in bronchiolitis. It is unclear whether enteral hydration is safe in children receiving high\u2010flow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a planned secondary analysis of a multi\u2010centre, randomised controlled trial of infants aged &lt;12\u2009months with bronchiolitis and an oxygen requirement. Children were assigned to treatment with either high\u2010flow or standard\u2010oxygen therapy with optional rescue high\u2010flow. We assessed adverse events based on how children on high\u2010flow were hydrated: intravenously (IV), via bolus or continuous nasogastric tube (NGT) or orally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 505 patients on high\u2010flow via primary study assignment (<jats:italic>n<\/jats:italic> = 408), primary treatment (<jats:italic>n<\/jats:italic> = 10) or as rescue therapy (<jats:italic>n<\/jats:italic> = 87) were assessed. While on high flow, 15 of 505 (3.0%) received only IV fluids, 360 (71.3%) received only enteral fluids and 93 (18.4%) received both IV and enteral fluids. The route was unknown in 37 (7.3%). Of the 453 high\u2010flow infants hydrated enterally patients could receive one or more methods of hydration; 80 (15.8%) received NGT bolus, 217 (43.0%) NGT continuous, 118 (23.4%) both bolus and continuous, 32 (6.3%) received only oral hydration and 171 (33.9%) a mix of NGT and oral hydration.<\/jats:p><jats:p>None of the patients receiving oral or NGT hydration on high\u2010flow sustained pulmonary aspiration (0%; 95% confidence interval N\/A); one patient had a pneumothorax (0.2%; 95% confidence interval 0.0\u20130.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The vast majority of children with hypoxic respiratory failure in bronchiolitis can be safely hydrated enterally during the period when they receive high\u2010flow.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14799","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T09:01:18Z","timestamp":1581411678000},"page":"950-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Enteral hydration in high\u2010flow therapy for infants with bronchiolitis: Secondary analysis of a randomised trial"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-2187","authenticated-orcid":false,"given":"Franz E","family":"Babl","sequence":"first","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"Emergency Department Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Clinical Sciences, Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Franklin","sequence":"additional","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"Pediatric Critical Care Research Group Queensland Children's Hospital and The University of Queensland  Brisbane Queensland Australia"},{"name":"Mater Research Institute The University of Queensland  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Critical Care Research Group, Adult Intensive Care Service The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luregn J","family":"Schlapbach","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Research Group Queensland Children's Hospital and The University of Queensland  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Critical Care Research Group, Adult Intensive Care Service The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Department of Pediatrics, Bern University Hospital, Inselspital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Oakley","sequence":"additional","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"Emergency Department Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Clinical Sciences, Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Dalziel","sequence":"additional","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"Children's Emergency Department Starship Children's Hospital  Auckland New Zealand"},{"name":"Liggins Institute University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Whitty","sequence":"additional","affiliation":[{"name":"Health Economics Group, Norwich Medical School University of East Anglia  Norwich United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Neutze","sequence":"additional","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"Emergency Department KidzFirst Middlemore Hospital  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Furyk","sequence":"additional","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"College of Medicine and Dentistry James Cook University  Townsville Queensland Australia"},{"name":"Emergency Department The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Craig","sequence":"additional","affiliation":[{"name":"Paediatric Research in Emergency Departments International Collaborative (PREDICT)  Melbourne Victoria Australia"},{"name":"Department of Medicine, School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Paediatric Emergency Department Monash Medical Centre, Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Fraser","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Research Group Queensland Children's Hospital and The University of Queensland  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schibler","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Research Group Queensland Children's Hospital and The University of Queensland  Brisbane Queensland Australia"},{"name":"Mater Research Institute The University of Queensland  Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Pediatrics, Bern University Hospital, Inselspital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Paediatric Research in Emergency Departments International Collaborative and Pediatric Critical Care Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284921"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2092"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1542\/peds.2015-2862","article-title":"Clinical practice guideline: The diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):e1474\u2010e1502","volume":"136","author":"Ralston SL","year":"2015","journal-title":"Pediatrics"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(12)70053-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.07.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300071"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2743-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503326"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12509"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2094-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30061-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714855"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0501-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31818eb2d1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e318188498c"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.5.483"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2000.tb02251.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.03.033"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1897"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.14799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.14799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:41:16Z","timestamp":1693615276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.14799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jpc.14799"],"URL":"https:\/\/doi.org\/10.1111\/jpc.14799","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"assertion":[{"value":"2019-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}