{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:53:24Z","timestamp":1792119204699,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["153\u201043773L"],"award-info":[{"award-number":["153\u201043773L"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["SUB\/1\/DN\/19\/005\/1143"],"award-info":[{"award-number":["SUB\/1\/DN\/19\/005\/1143"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine the relation of non\u2010invasive markers representing gut mucosal damage (metalloproteinase\u20109 (MMP\u20109)) and remodelling (tissue inhibitor of metalloproteinase\u20101 (TIMP\u20101)) with Crohn's disease (CD) phenotype, disease activity scores (clinical and endoscopic) and radiological evaluation of the ileum in newly diagnosed children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum and faecal MMP\u20109 and TIMP\u20101 concentrations were determined with the sandwich enzyme\u2010linked immunoassay technique. The performance of each marker with reference to the Paris classification, disease activity scores and magnetic resonance enterography results was assessed using non\u2010parametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 32 children with CD demonstrated higher levels of serum and faecal MMP\u20109 and TIMP\u20101 compared with a control group including children without gastrointestinal inflammatory disease (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Only the serum MMP\u20109 concentration was significantly higher in children with L3 (ileocolonic) compared with children with L1 (distal ileum). The serum TIMP\u20101 level was significantly higher in patients with an magnetic resonance enterography\u2010detected ileum involvement longer than 51\u2009mm and in children with severe disease activity compared with other patients. The serum MMP\u20109 level was lower in patients with stenosis combined with prestenotic dilation compared with children without stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased serum and faecal MMP\u20109 and TIMP\u20101 concentrations are some reliable markers of inflammation in newly diagnosed children with CD, but without facilitating clear phenotyping of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14908","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T11:45:52Z","timestamp":1588592752000},"page":"1233-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of metalloproteinase\u20109 and tissue inhibitor of metalloproteinase\u20101 in clinical characterisation of children with newly diagnosed Crohn's disease"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-6578","authenticated-orcid":false,"given":"Urszula","family":"Daniluk","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Daniluk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Guzinska\u2010Ustymowicz","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pryczynicz","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Lebensztejn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy190"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1936315"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy402"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.120"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2018.08.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1775-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336995"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1936-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20419"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-55"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.677954"},{"key":"e_1_2_6_13_1","first-page":"1014","article-title":"A phase 2, randomized, placebo\u2010controlled study evaluating matrix metalloproteinase\u20109 inhibitor, andecaliximab, in patients with moderately to severely active Crohn's disease","volume":"12","author":"Schreiber S","year":"2018","journal-title":"J. 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