{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T20:15:32Z","timestamp":1776024932654,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of cows milk protein allergy (CMPA) is not always easy. Cow's Milk\u2010related Symptom Score (CoMiSS) has been developed to raise the awareness of CMPA among the primary health\u2010care providers. In this study, we aimed to evaluate the validity of CoMiSS as a diagnostic approach of CMPA in infants in our country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants with a CoMiSS of more than 12 points were included. An elimination diet was implemented in these infants for 4 weeks, and CoMiSS was reapplied. Infants with a reduction of \u22653 points in CoMiSS were considered responsive to the elimination diet, and an open oral challenge test was performed. Infants with symptom recurrence were diagnosed with CMPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 168 infants. When they were included in the study, the first CoMiSS score was 13.6\u2009\u00b1\u20091.9. After the elimination diet, the number of responsive infants was 154 (91.7%). Of the infants, 91 (54.2%) were diagnosed with CMPA with positive challenge. The majority of the patients diagnosed with CMPA presented with gastrointestinal and\/or dermatological symptoms (80.3%). Positive family history of allergy was more prevalent in CMPA(+) infants (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The mean atopic dermatitis score was higher in CMPA(+) infants (<jats:italic>P<\/jats:italic> = 0.001). Eosinophilia and cows milk\u2010specific IgE (CM\u2010sIgE) positivity were more prevalent in infants with CMPA (<jats:italic>P\u2009=<\/jats:italic> 0.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CoMiSS is a valuable tool to evaluate CMPA in primary care. The presence of multiple symptoms, especially skin involvement, helps to recognise infants with CMPA. Family history and eosinophilia also support the diagnosis of CMPA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.14921","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T08:25:37Z","timestamp":1590740737000},"page":"1799-1805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of cows milk\u2010related symptom scoring awareness tool in young Turkish children"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-4112","authenticated-orcid":false,"given":"Suna Kaymak","family":"Selbuz","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansu","family":"Altunta\u015f","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydan","family":"Kansu","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceyda Tuna","family":"K\u0131rsa\u00e7l\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarife","family":"Kulo\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisa Eda \u00c7ullas","family":"\u0130larslan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"Do\u011fulu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-8176","authenticated-orcid":false,"given":"Fatih","family":"G\u00fcnay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Top\u00e7u","sequence":"additional","affiliation":[{"name":"Division of Social Pediatrics Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"Ulukol","sequence":"additional","affiliation":[{"name":"Division of Social Pediatrics Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.05.026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31825c9482"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2016.01.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12902"},{"key":"e_1_2_7_7_1","first-page":"1258","article-title":"Approach to milk protein allergy in infants","volume":"54","author":"Brill H","year":"2008","journal-title":"Can Fam. 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