{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:49:24Z","timestamp":1770518964791,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003189","name":"Freemasons New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To circumvent the need for an endoscopic biopsy to establish the diagnosis of coeliac disease (CD), the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) introduced a non\u2010biopsy pathway for selected children in 2012. This pathway was recently updated to utilise anti\u2010tissue transglutaminase IgA (anti\u2010TTG IgA), 10\u00d7 upper limit of normal (ULN) and positive endomysial antibodies (EMA). This study focused on the retrospective application of these guidelines in children from two regions of New Zealand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged &lt;18\u2009years who had anti\u2010TTG IgA measured and underwent oesophagogastroduodenoscopy over a 30\u2010month period were identified retrospectively. Medical records were reviewed to determine whether patients subsequently had biopsy\u2010proven CD (Marsh \u22652).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty\u2010six children, with a mean age (\u00b1standard deviation) of 9.9\u2009\u00b1\u20094.2\u2009years, fulfilled the study criteria and 101 (74%) of these children had positive anti\u2010TTG IgA. Eighty\u2010two of 136 (60%) children had biopsy\u2010proven CD. Positive anti\u2010TTG IgA and EMA were highly sensitive in diagnosing CD, 96.3 and 98.6%, respectively. Anti\u2010TTG\u2010IgA \u226510\u00d7 ULN alone, and combined anti\u2010TTG IgA \u226510\u00d7 ULN with positive EMA, both provided positive predictive values of 100% in diagnosing CD. Nineteen of 103 (18%) children could have been diagnosed with CD based on the ESPGHAN non\u2010biopsy criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A proportion of New Zealand children with CD can potentially be diagnosed using the latest ESPGHAN non\u2010biopsy criteria. 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