{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:32Z","timestamp":1747186652969,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Differentiating left heart obstruction (LHO) from other severe illness in the neonatal period is challenging, and important for guiding clinical management. The aim of this study was to identify factors distinguishing LHO from non\u2010LHO in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, cohort study of neonates referred to the Newborn and Paediatric Emergency Transport Service, New South Wales, with suspected LHO during the epoch 1996\u20132016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 273 neonates were included; 240 with confirmed LHO. Administration of prostaglandin E<jats:sub>1<\/jats:sub> to infants with a structurally normal heart was not associated with impaired acid\u2013base or oxygenation status. Pre\u2010transport diagnostic accuracy of LHO was 74.4%; sensitivity 84.5%, positive predictive value 86.0%. On multivariable logistic regression, hepatomegaly (odds ratio 2.54; 95% confidence interval 1.05\u20136.16) was associated with confirmed LHO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low threshold for prostaglandin E<jats:sub>1<\/jats:sub> infusion should be maintained in infants with suspected LHO. Hepatomegaly is associated with a diagnosis of LHO and may be more useful than other parameters in predicting the condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15102","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T07:49:07Z","timestamp":1597045747000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improving diagnostic accuracy in neonates with left heart obstruction in a transport setting"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-1817","authenticated-orcid":false,"given":"Stephanie M","family":"Boyd","sequence":"first","affiliation":[{"name":"Newborn and Paediatric Emergency Transport Service (NETS) New South Wales  Sydney New South Wales Australia"},{"name":"Grace Centre for Newborn Intensive Care The Children's Hospital at Westmead  Sydney New South Wales 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