{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:42Z","timestamp":1747186662551,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to examine the adverse event (AE) rate for intrathecal baclofen (ITB) therapy in an Australian paediatric population and to clarify type and frequency of AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AE data were extracted from the Australian Paediatric ITB Research Group national database, to include the first 5\u2009years of data collection. Raw data were collated and analysed descriptively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected for 40 patients. Forty\u2010seven AEs in 23 patients were reported. Ten (25%) patients required surgical intervention related to their AE. Five patients (12.5%) required pump removal. The most frequent ITB\u2010related AEs were catheter dysfunction (24%), drug overdose, withdrawal or sensitivity (19%), seromas and haematomas (15%) and infections (13%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The AE rate for ITB therapy is high and needs to be considered when counselling patients regarding ITB as a therapeutic option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15194","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T12:39:42Z","timestamp":1601037582000},"page":"258-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adverse events associated with paediatric intrathecal baclofen in Australia: 5\u2009years of data collection"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5417-3984","authenticated-orcid":false,"given":"Louise","family":"Tyack","sequence":"first","affiliation":[{"name":"Queensland Paediatric Rehabilitation Service Queensland Children's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Copeland","sequence":"additional","affiliation":[{"name":"Queensland Paediatric Rehabilitation Service Queensland Children's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"McCartney","sequence":"additional","affiliation":[{"name":"Kids Rehab The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary\u2010Clare","family":"Waugh","sequence":"additional","affiliation":[{"name":"Kids Rehab The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"CD004552","article-title":"Intrathecal baclofen for treating spasticity in children with cerebral palsy","author":"Hasnat MJ","year":"2015","journal-title":"Cochrane Database Syst. 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