{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:46:39Z","timestamp":1785577599251,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Adipokines and hepatokines are proteins secreted by adipose tissue and the liver. To date, the levels of adipokines and hepatokines in cholelithiasis have only been evaluated in studies in adult patients. The purpose of our research was to assess the levels of circulating adipokines: chemerin, vaspin, progranulin, retinol\u2010binding protein 4 (RBP\u20104) and hepatokine: fibroblast growth factor 21 (FGF\u201021) and to compare their concentrations in paediatric patients with and without cholelithiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective study included 54 children and adolescents diagnosed with gallstones and 26 controls. Fasting serum levels of adipokines and hepatokine were determined by enzyme\u2010linked immunosorbent assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum levels of chemerin, FGF\u201021 and RBP\u20104 were significantly higher in children and adolescents with gallstones compared to the control group. Elevated levels of triglycerides, RBP\u20104, and a homeostatic model for assessing insulin resistance (HOMA\u2010IR) were observed in overweight or obese patients compared to patients with normal weight and cholelithiasis. Chemerin concentrations were increased in the normal\u2010weight children and adolescents with cholelithiasis compared to the control group. Children and adolescents with gallstones and abnormal weight had significantly higher levels of chemerin, FGF\u201021 and RBP\u20104 than healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated serum chemerin levels were significantly higher in non\u2010obese patients with cholelithiasis than in non\u2010obese controls, suggesting a potential role of chemerin in the development of cholelithiasis in children and adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15223","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T03:24:22Z","timestamp":1602473062000},"page":"371-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of chemerin in the pathogenesis of cholelithiasis in children and adolescents"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-911X","authenticated-orcid":false,"given":"Katarzyna","family":"Zdanowicz","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Hepatology, Nutrition and Allergology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ryzko","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Hepatology, Nutrition and Allergology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bobrus\u2010Chociej","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Hepatology, Nutrition and Allergology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Wojtkowska","sequence":"additional","affiliation":[{"name":"Department of Radiology University Teaching Children's Hospital  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz Marek","family":"Lebensztejn","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Hepatology, Nutrition and Allergology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000726"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12935"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.24"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12997"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2016_1252"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0174"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179556519853780"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2937"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-014-0084-4"},{"key":"e_1_2_6_11_1","first-page":"457","article-title":"Circulating adipokines in children with nonalcoholic fatty liver disease: Possible noninvasive diagnostic markers","volume":"30","author":"Mohamed AA","year":"2017","journal-title":"Ann. 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