{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:08:55Z","timestamp":1789193335526,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Secondary prophylaxis with 3\u20134 weekly benzathine penicillin G injections is necessary to prevent disease morbidity and cardiac mortality in patients with acute rheumatic fever (ARF) and rheumatic heart disease (RHD). This study aimed to determine secondary prophylaxis adherence rates in the Far North Queensland paediatric population and to identify factors contributing to suboptimal adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of data recorded in the online RHD register for Queensland, Australia, was performed for a 10\u2010year study period. The proportion of benzathine penicillin G injections delivered within intervals of \u226428\u2009days and \u226435\u2009days was measured. A multi\u2010level mixed model logistic regression assessed the influence of age, gender, ethnicity, suburb, Accessibility and Remoteness Index of Australia class, number of people per dwelling, Index of Relative Socio\u2010economic Advantage and Disadvantage, Index of Education and Occupation, year of inclusion on an ARF\/RHD register and individual effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 277 children and analysis of 7374 injections. No children received \u226580% of recommended injections within a 28\u2010day interval. Four percent received \u226550% of injections within \u226428\u2009days and 46% received \u226550% of injections at an extended interval of \u226435\u2009days. Increasing age was associated with reduced delivery of injections within 35\u2009days. Increasing year of inclusion was associated with improved delivery within 28\u2009days. The random effect of individual patients was significantly associated with adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Improved timely delivery of secondary prophylaxis for ARF and RHD is needed as current adherence is very low. Interventions should focus on factors specific to each individual child or family unit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15239","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T12:51:50Z","timestamp":1608382310000},"page":"419-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Adherence rates and risk factors for suboptimal adherence to secondary prophylaxis for rheumatic fever"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-2068","authenticated-orcid":false,"given":"Priya M","family":"Kevat","sequence":"first","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"},{"name":"Clinical Services Apunipima Cape York Health Council  Cairns Queensland Australia"},{"name":"Department of Paediatrics Cairns and Hinterland Hospital and Health Service  Cairns Queensland Australia"},{"name":"The Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"},{"name":"Research, Development, Education and Innovation Primary Health Care  Gothenburg Region V\u00e4stra G\u00f6taland Sweden"},{"name":"General Practice\/Family Medicine, Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Cairns and Hinterland Hospital and Health Service  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R","family":"Ruben","sequence":"additional","affiliation":[{"name":"Clinical Services Apunipima Cape York Health Council  Cairns Queensland Australia"},{"name":"Medical Services, Torres and Cape Hospital and Health Service  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Cardiovascular Disease: Australian Facts 2011","author":"Australian Institute of Health and Welfare","year":"2011"},{"key":"e_1_2_7_3_1","volume-title":"Acute Rheumatic Fever and Rheumatic Heart Disease in Australia","author":"Australian Institute of Health and Welfare","year":"2019"},{"key":"e_1_2_7_4_1","volume-title":"The 2020 Australian Guideline for Prevention, Diagnosis and Management of Acute Rheumatic Fever and Rheumatic Heart Disease","author":"RHDAustralia (ARF\/RHD Writing Group)","year":"2020"},{"key":"e_1_2_7_5_1","volume-title":"Rheumatic Fever and Rheumatic Heart Disease: Report of a WHO Expert Consultation, Geneva, 20 October\u20131 November 2001","author":"WHO Study Group on Rheumatic Fever and Rheumatic Heart Disease, World Health Organisation","year":"2004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X13666170116120828"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2005.tb00243.x"},{"key":"e_1_2_7_8_1","first-page":"1464","article-title":"Prophylactic penicillin by the full moon: A novel approach in Central Australia that may help to reduce the risk of rheumatic heart disease","volume":"10","author":"Kearns TM","year":"2010","journal-title":"Rural Remote Health"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02838.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1584.2007.00896.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2002.tb00340.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00347.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009308"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH19132"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-13-525"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12379"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010223"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50498"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12796"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2013-022"},{"key":"e_1_2_7_21_1","first-page":"282","article-title":"Compliance of secondary prophylaxis for controlling rheumatic fever and rheumatic heart disease in a rural area of northern India","volume":"49","author":"Kumar R","year":"1997","journal-title":"Indian Heart J."},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.26719\/2000.6.2-3.437","article-title":"Profile of secondary prophylaxis among children with rheumatic heart disease in Alexandria, Egypt","volume":"6","author":"Bassili A","year":"2000","journal-title":"East. Mediterr. Health J."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-131"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178264"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.15239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:03:49Z","timestamp":1693580629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.15239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,19]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/jpc.15239"],"URL":"https:\/\/doi.org\/10.1111\/jpc.15239","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,19]]},"assertion":[{"value":"2020-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}