{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:47Z","timestamp":1747186667805,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>While mostly eradicated in developed nations, rheumatic heart disease (RHD) is still the leading cause of preventable cardiovascular disease in children. RHD and its antecedent acute rheumatic fever remain endemic in many low to middle income countries, as well as in vulnerable communities in wealthy ones. Evidence\u2010based interventions are particularly important in resource\u2010poor settings. We sought to determine if efforts directed at patient and family education impact degree of participation in community\u2010based prevention measures, and with short\u2010term disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an observational, cross\u2010sectional study of children with RHD aged 5\u201319\u2009years, along with their parents, in American Samoa. A survey was administered in November 2016 to assess patient and parent knowledge of RHD. Scores were compared to percent timeliness of penicillin prophylaxis via chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We collected a total of 70 surveys of child\u2013parent dyads with a patient mean age of 14.28\u2009years \u00b12.71. An increased knowledge score was predictive of increased penicillin compliance for both children (12.70% increase in compliance per 1\u2010unit increase in score (<jats:italic>P<\/jats:italic> =\u20090.0004)) and parents (10.10% increase in compliance per 1\u2010unit increase in score (<jats:italic>P<\/jats:italic> =\u20090.0012)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A clear relationship exists between patient and parent knowledge of RHD and timeliness of penicillin prophylaxis doses. This study was the first to link patient understanding of RHD to engagement with preventative measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15249","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T01:43:40Z","timestamp":1603590220000},"page":"513-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between patient understanding and timeliness of penicillin prophylaxis in rheumatic heart disease prevention programmes in American Samoa"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3350-6839","authenticated-orcid":false,"given":"Jennifer H","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Oregon Health and Science University  Portland Oregon United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callia","family":"Elkhal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oregon Health and Science University  Portland Oregon United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ipuniuesea","family":"Eliapo\u2010Unutoa","sequence":"additional","affiliation":[{"name":"Department of Health American Samoa Government  Fagaalu American Samoa United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie R","family":"Armsby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oregon Health and Science University  Portland Oregon United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin J","family":"Madriago","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oregon Health and Science University  Portland Oregon United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S12977"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603693"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.1o816.x"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"Group A streptococcal diseases and their global burden","volume":"368","author":"Ralph AP","year":"2013","journal-title":"Curr. 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