{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:49Z","timestamp":1747186669730,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>To undertake a literature search and critical appraisal of best available evidence to answer the clinical question: Does the addition of clonidine (I) to standard treatment with an opioid (C) improve outcomes (O) in infants with Neonatal Abstinence Syndrome? A search of both comprehensive (MedLine and Embase) and pre\u2010filtered databases (Dynamed, UpToDate and TRIP), utilising Boolean Operators to combine search terms appropriately. Three relevant studies were identified. One paper describing the outcomes of a randomised controlled trial by Agthe <jats:italic>et al<\/jats:italic>. (2009) most accurately answered the clinical question posed. This paper was critically appraised, and evidence applied to the clinical scenario. The use of clonidine as an adjunct to opioid in the management of infants with NAS reduces the total number of treatment days and dose of opioid required to control symptoms. However, there is a higher risk of rebound in symptoms post\u2010cessation of opioid and clinicians need to account for this in their discharge planning. More large scale, multi\u2010centre high\u2010quality research is needed to clarify the role of clonidine in the treatment of NAS: as monotherapy versus adjunct, the optimal dose and longer\u2010term impact on neurodevelopment.<\/jats:p>","DOI":"10.1111\/jpc.15265","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T22:27:34Z","timestamp":1611613654000},"page":"155-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does the addition of clonidine to opioid therapy improve outcomes in infants with Neonatal Abstinence Syndrome?"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-1365","authenticated-orcid":false,"given":"Elise","family":"D'Abaco","sequence":"first","affiliation":[{"name":"Paediatric Medicine, Western Health Joan Kirmer Women's and Children's Hospital  Melbourne Victoria Australia"},{"name":"The University of Sydney Faculty of Medicine and Health  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1542\/peds.2008-0978"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1007\/s40199-019-00266-3"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1001\/jamapediatrics.2018.5044"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.2174\/1574887112666170816144818"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1053\/j.semperi.2019.01.007"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1016\/j.siny.2019.01.009"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1093\/pch\/pxx199"},{"unstructured":"Oxford Uo.Oxford Centre for Evidence Based Medicine Oxford U.K. 2019. 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Available from:https:\/\/www.uptodate.com\/contents\/infants-with-fetal-intrauterine-growth-restriction?search=barker%20hypothesis&source=search_result&selectedTitle=1~7&usage_type=default&display_rank=1-H21[accessed 4 November 2019].","key":"e_1_2_9_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1111\/j.1360-0443.2012.04038.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1016\/j.jpeds.2019.12.018"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1136\/eb-2018-102948"},{"unstructured":"Opium tincture: Drug information: Up To Date;2019. 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