{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:39:09Z","timestamp":1788881949449,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To characterise <jats:italic>Bartonella<\/jats:italic> infections in a paediatric population requiring hospital admission and review its treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal observational retrospective data analysis of children and adolescents admitted with <jats:italic>Bartonella<\/jats:italic> infection at a paediatric tertiary hospital from 2010 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 16 cases of bartonellosis, with a mean age of 8.0\u2009\u00b1\u20094.5\u2009years old, no sex predominance and 14 had contact with cats. Most of the cases occurred in fall and winter. Clinical presentations included osteomyelitis\/arthritis (<jats:italic>n<\/jats:italic>\u00a0=\u20099), hepatosplenic disease (<jats:italic>n<\/jats:italic>\u00a0=\u20092), lymphadenitis (<jats:italic>n<\/jats:italic>\u00a0=\u20092), neuroretinitis (<jats:italic>n<\/jats:italic>\u00a0=\u20092) and encephalitis (<jats:italic>n<\/jats:italic>\u00a0=\u20091). Clinical diagnosis was confirmed by serology (<jats:italic>n<\/jats:italic>\u00a0=\u200916) and <jats:italic>Bartonella<\/jats:italic> DNA detection in patient's lymph nodes\/hepatic lesion (<jats:italic>n<\/jats:italic>\u00a0=\u20093). Therapeutic approach varied according to the clinical presentation: azithromycin in lymphadenitis, rifampicin plus ciprofloxacin in hepatosplenic disease, rifampicin and doxycycline in neuroretinitis, ceftriaxone in encephalitis and azithromycin, cotrimoxazole or rifampicin plus azithromycin, cefuroxime, ciprofloxacin or doxycycline in osteomyelitis\/arthritis. Immunodeficiency was excluded in seven patients. Seven patients' cats were screened by veterinarians and treated when infected (<jats:italic>n<\/jats:italic>\u00a0=\u20095).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In these clinical presentations, where other infections may be involved, a high index of suspicion is necessary, with emphasis on the epidemiological context. The association of systemic forms with immunodeficiency did not occur in our study. The lack of recommendations for treatment of atypical infection makes the approach of these cases a challenge. Randomised control studies are essential to define the best approach in each case.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15304","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T02:17:06Z","timestamp":1607653026000},"page":"653-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Atypical bartonellosis in children: What do we know?"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-4280","authenticated-orcid":false,"given":"Ana P","family":"Lemos","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Hospital Dona Estef\u00e2nia  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Domingues","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Dona Estef\u00e2nia  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Dona Estef\u00e2nia  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Centre of Study of Vectors and Infectious Diseases National Institute of Health Dr. Ricardo Jorge  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Dona Estef\u00e2nia  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762010000700006"},{"key":"e_1_2_8_3_1","first-page":"58","article-title":"Cat\u2010scratch disease: Clinical considerations for pediatric dentist","volume":"31","author":"Da Silva K","year":"2009","journal-title":"Pediatr. 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