{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:20:44Z","timestamp":1764937244492,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To characterise the physical, psychological, and quality of life burden associated with serogroup B invasive meningococcal disease (IMD) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged up to 14\u2009years at the time of serogroup B IMD, who were admitted to intensive care units of two tertiary paediatric hospitals in New South Wales, Australia between January 2009 and December 2013 were recruited. Children underwent clinical and neuropsychological assessments up to 6\u2009years post\u2010disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven children were assessed, with a median age of 16\u2009months (range 4\u201346\u2009months) at time of disease. The median follow\u2010up time was 50\u2009months (range 10\u201367\u2009months). Seven (63.6%) cases had one or more long\u2010term sequelae involving permanent and evolving physical disability. Three cases had ongoing medical conditions including two with seizures and one with ataxia and hypermetropia. Five required ongoing medical and allied health care. Other complications identified included anxiety, speech delay, low average full\u2010scale IQ score (median 85, interquartile range 89\u2013103) and borderline memory impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serogroup B IMD is associated with significant long\u2010term morbidity and burden on the child and family with substantial economic implications. The impact of this on the total cost of IMD needs to be further quantified, and better considered in vaccine cost\u2010effectiveness analyses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15350","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T17:38:25Z","timestamp":1610991505000},"page":"894-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longer term outcomes following serogroup B invasive meningococcal disease"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0066-2218","authenticated-orcid":false,"given":"Lucy","family":"Deng","sequence":"first","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Barton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"},{"name":"Children's Hospital Education Research Institute The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Kids Neuroscience Centre The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harunor","family":"Rashid","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Dastouri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Booy","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38968.683958.AE"},{"key":"e_1_2_7_3_1","first-page":"E503","article-title":"Australian Meningococcal Surveillance Programme annual report, 2015","volume":"40","author":"Lahra MM","year":"2016","journal-title":"Commun. 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