{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:56:21Z","timestamp":1768006581308,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to investigate the effects of vitamin B12 deficiency on hearing in school\u2010aged children by pure\u2010tone audiometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three vitamin B12\u2010deficient children and 37 age\u2010matched control subjects were enrolled in the study. Tympanometric evaluations and pure\u2010tone audiometry including high frequencies were performed on the subjects. The results were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both right and left ear pure\u2010tone hearing thresholds (PTHTs) at 0.25\u20134\u00a0kHz, and four\u2010frequency pure\u2010tone average values were significantly better in the control group compared with the patient group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, PTHTs at 8\u201316\u2009kHz were not different between the two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Vitamin B12 level also did not show any significant correlation with the PTHTs at 0.25\u201316\u2009kHz (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates that vitamin B12 deficiency may contribute to hearing impairment at low frequencies as a possible aetiological factor in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15392","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T18:25:52Z","timestamp":1613672752000},"page":"1060-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hearing status in vitamin B12\u2010deficient children"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-7784","authenticated-orcid":false,"given":"Arzu","family":"Akyay","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Hematology and Oncology Inonu University  Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Soylu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Otorhinolaryngology Medipol University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Faculty of Health Science, Department of Language and Speech Therapy \u0130stinye University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Demirol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Gastroenterology and Hepatology F\u0131rat University  Elaz\u0131\u011f Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semiha","family":"Bah\u00e7eci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunologyy \u00c7i\u011fli Training and Research Hospital  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112160"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.676"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12292"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00031.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.3631"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512004291"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.3.564"},{"key":"e_1_2_7_9_1","first-page":"1","article-title":"Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women","volume":"18","author":"Karaer I","year":"2019","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90046-A"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090417"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1300\/J052v25n03_08"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.08.031"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.122010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000469"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/57.1.47"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1403-101"},{"key":"e_1_2_7_18_1","first-page":"82","volume-title":"Handbook of Clinical Audiology","author":"Harrell RW","year":"2002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.10.013"},{"key":"e_1_2_7_20_1","first-page":"243","article-title":"Effect of vitamin B12 deficiency on otoacoustic emissions","volume":"33","author":"Karl\u0131 R","year":"2013","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"e_1_2_7_21_1","first-page":"1","article-title":"Vestibular evoked myogenic potentials in patients with low vitamin B12 levels","volume":"98","author":"\u00d6zdemir D","year":"2019","journal-title":"Ear Nose Throat J."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.t01-1-00507.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005631230455"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2003.11.019"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830513Y.0000000073"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12541"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.15392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:52:54Z","timestamp":1692654774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.15392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jpc.15392"],"URL":"https:\/\/doi.org\/10.1111\/jpc.15392","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"2020-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}