{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:16:47Z","timestamp":1792124207995,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["95\u201001\u201001\u201014023"],"award-info":[{"award-number":["95\u201001\u201001\u201014023"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to investigate the effect of adding ursodeoxycholic acid (UDCA) to phototherapy in neonates with glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency and hyperbilirubinaemia. G6PD deficiency is a common cause of severe hyperbilirubinaemia in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a triple blind, clinical trial study of 40 neonates with G6PD deficiency and hyperbilirubinaemia who admitted for phototherapy in hospitals affiliated to the University of Medical Sciences. The treatment group (<jats:italic>n<\/jats:italic>\u00a0=\u200920) received UDCA 10\u00a0mg\/kg (2\u00a0cc\/kg) daily divided into 2 doses every 12\u2009h. The control group (<jats:italic>n<\/jats:italic>\u00a0=\u200920) received the same volume of placebo syrup. The drug and placebo treatments were continued until the bilirubin level dropped below 171\u2009\u03bcmol\/L. Both the control and treatment group received continuous phototherapy. Independent sample <jats:italic>t<\/jats:italic>\u2010test, survival analysis and logrank test were used to statistically analyse the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean total bilirubin level was 231.9\u00a0\u00b1\u200918.8\u00a0\u03bcmol\/L and 184.3\u00a0\u00b1\u200918.6\u00a0\u03bcmol\/L in the control and intervention group respectively, 24\u2009h after drug administration and 209.7\u00a0\u00b1\u200919.3\u00a0\u03bcmol\/L and 157.4\u00a0\u00b1\u200916.4\u00a0\u03bcmol\/L, respectively, 48\u2009h after intervention (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The median length of hospitalisation in the treatment group was approximately 1\u00a0day lower than the control group (logrank test <jats:italic>P<\/jats:italic> value: &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study showed that the addition of UDCA to phototherapy accelerates the reduction of total bilirubin level in neonates with G6PD deficiency and can reduce the duration of hospitalisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15411","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:31:09Z","timestamp":1615206669000},"page":"1175-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating the effect of ursodeoxycholic acid on total bilirubin of neonates with glucose\u20106\u2010phosphate dehydrogenase deficiency complicated by indirect hyperbilirubinaemia"],"prefix":"10.1111","volume":"57","author":[{"given":"Mehrdad","family":"Rezaie","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Department of Pediatric Medicine and Neonatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Gholami","sequence":"additional","affiliation":[{"name":"Department of Family medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Jafari","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-5664","authenticated-orcid":false,"given":"Hourvash","family":"Haghighinejad","sequence":"additional","affiliation":[{"name":"Department of Family medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4102\/phcfm.v10i1.1582"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3499"},{"key":"e_1_2_7_4_1","unstructured":"WongR BhutaniVB.Unconjugated Hyperbilirubinemia in Term and Late Preterm Infants: Epidemiology and Clinical Manifestations. 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