{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:28:01Z","timestamp":1790011681976,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","award":["Postgraduate Award"],"award-info":[{"award-number":["Postgraduate Award"]}],"id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","award":["Summer Research Scholarship"],"award-info":[{"award-number":["Summer Research Scholarship"]}],"id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","award":["University of Sydney Postgraduate Award"],"award-info":[{"award-number":["University of Sydney Postgraduate Award"]}],"id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections in children and the development of vaccines to protect at\u2010risk groups is a global priority. The aim of this study was to describe RSV subtype circulation patterns and associated disease severity to inform on potential impact of an RSV\u2010specific prevention strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010centre retrospective observational study of children aged &lt;16\u2009years with laboratory\u2010confirmed RSV infection from 2014 to 2018 inclusive. We described the features and frequency of all RSV subtype detections. We selected a random sample of RSV\u2010A and RSV\u2010B cases from each year (<jats:italic>n<\/jats:italic>\u00a0=\u00a0200), described demographic and clinical features of these cases, and compared indicators of disease severity between subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 3591 RSV detections over a 5\u2010year period and found consistent co\u2010circulation of subtypes with alternating predominance. Demographic and clinical characteristics were similar between children presenting with RSV\u2010A and RSV\u2010B infections. There was no difference in indicators of severity between the subtypes except for paediatric intensive care unit length of stay which was longer in the RSV\u2010B group (3 vs. 5\u2009days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). Respiratory co\u2010infections were more frequent in the RSV\u2010B group (41.8% vs. 27.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035). When these were excluded there was no longer a detectable difference in paediatric intensive care unit length of stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found co\u2010circulation of RSV subtypes and no convincing evidence of a difference in disease severity between subtypes. RSV\u2010specific interventions will need to be equally effective against both RSV\u2010A and RSV\u2010B to have the greatest impact on reducing severe RSV disease in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15419","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T15:52:36Z","timestamp":1614441156000},"page":"1190-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Respiratory syncytial virus subtype circulation and associated disease severity at an Australian paediatric referral hospital, 2014\u20132018"],"prefix":"10.1111","volume":"57","author":[{"given":"Gemma L","family":"Saravanos","sequence":"first","affiliation":[{"name":"Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"},{"name":"National Centre for Immunisation Research and Surveillance  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-8682","authenticated-orcid":false,"given":"Isabelle","family":"Ramos","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance  Sydney New South Wales Australia"},{"name":"School of Medicine University of Notre Dame Fremantle  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-6000","authenticated-orcid":false,"given":"Philip N","family":"Britton","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases and Microbiology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Wood","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"},{"name":"National Centre for Immunisation Research and Surveillance  Sydney New South Wales Australia"},{"name":"Department of General Medicine The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50159"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815003015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.09.092"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011398"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081717"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-10-2111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318282603a"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-019-0704-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001596"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.01.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/513976"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy496"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199310000-00004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821994000100001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12414"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix543"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21026"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908380"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913556"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165108"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10090476"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0303"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12688"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199812000-00003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/498526"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/342414"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.15419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:03:48Z","timestamp":1692666228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.15419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,27]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jpc.15419"],"URL":"https:\/\/doi.org\/10.1111\/jpc.15419","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,27]]},"assertion":[{"value":"2020-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}