{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:53:48Z","timestamp":1781038428663,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Oral medications are often first\u2010line medical management for children with cerebral palsy who have generalised dystonia; however, evidence for their effectiveness is limited and dosing practices are inconsistent. As a first step to improve consistency, this study aimed to examine current clinical practice of expert doctors for prescribing medications for children with dystonic cerebral palsy including prescribing patterns and combinations of medications used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective surveillance study of medical doctors working in major Australian centres who manage children with cerebral palsy. Each week over a continuous 6\u2010month period, doctors completed a custom developed online survey for children seen that week with dystonic cerebral palsy for whom they prescribed a new medication to treat dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five doctors consented to participate, 16 of whom prescribed new medications for dystonia in children with cerebral palsy over the study period. There were 77 children who were prescribed new medications. Baclofen and gabapentin were prescribed most, followed by levodopa, trihexyphenidyl and diazepam. The most common combinations of medications were baclofen and diazepam or baclofen and gabapentin. Dosage regimens were variable, particularly for trihexyphenidyl and diazepam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inconsistencies in dosing regimens remain for oral medication prescription by Australian doctors when managing dystonia in cerebral palsy. Future studies using the consensus of expert clinicians will be conducted to develop guidelines in an area where the evidence for individual medications is extremely limited.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15429","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T09:50:02Z","timestamp":1614765002000},"page":"1222-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["National surveillance of oral medication prescription for children with dystonic cerebral palsy"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8294-7382","authenticated-orcid":false,"given":"Adrienne","family":"Harvey","sequence":"first","affiliation":[{"name":"Neurodisability and Rehabilitation Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Neurodevelopment and Disability Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Bear","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Notre Dame  Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Rice","sequence":"additional","affiliation":[{"name":"Paediatric Rehabilitation Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Antolovich","sequence":"additional","affiliation":[{"name":"Neurodisability and Rehabilitation Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Neurodevelopment and Disability Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Clare","family":"Waugh","sequence":"additional","affiliation":[{"name":"Kids Rehab The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e89"},{"key":"e_1_2_7_3_1","volume-title":"Report of the Australian Cerebral Palsy Register, Birth Years 1995\u20132012","author":"ACPR Group","year":"2018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.144014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13166"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13652"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13754"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316309"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012430.pub2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2015.09.007"},{"key":"e_1_2_7_11_1","first-page":"179","article-title":"A pilot study of gabapentin for managing pain in children with dystonic cerebral palsy","volume":"61","author":"Harvey A","year":"2019","journal-title":"Dev. 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Child Neurol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13532"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbcd2f"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.15429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:04:01Z","timestamp":1692666241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.15429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jpc.15429"],"URL":"https:\/\/doi.org\/10.1111\/jpc.15429","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"2020-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}