{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:38:07Z","timestamp":1747186687025,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To conduct a prospective, consecutive cohort study to evaluate the incidence of allergen\u2010specific and total <jats:styled-content style=\"fixed-case\">immunoglobulin E (<\/jats:styled-content>IgE) in a paediatric population undergoing adenotonsillectomy for sleep\u2010disordered breathing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 64 consecutive patients presenting for adenotonsillectomy at a single centre were recruited over a period of 3\u00a0months. All patients underwent adenotonsillectomy and had allergen\u2010specific and total IgE serum testing at the time of anaesthesia induction. Pre\u2010operative history and examination were conducted to determine clinical allergy. Caregivers completed the Sleep\u2010Related Breathing Disorder scale of the Paediatric Sleep Questionnaire and the Mini Rhinoconjunctivitis Quality of Life Questionnaire at baseline and at 6\u2009weeks post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 (57.8%) patients had either allergen\u2010specific or total IgE positivity. House dust mite was the most prevalent allergen\u2010specific IgE finding, being present in moderate to high levels in 14 (21.9%) patients. A total of 17 (26.6%) patients had a history of atopy, while 34 (53.1%) had examination findings suggestive of allergy. Neither serum IgE testing nor clinical history and examination were independently associated with residual symptoms post adenotonsillectomy. Patients with concomitant serum IgE positivity and clinical allergy had higher residual symptom scores compared to those who did not using both Sleep\u2010Related Breathing Disorder scale of the Paediatric Sleep Questionnaire (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035) and Mini Rhinoconjunctivitis Quality of Life Questionnaire (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our prospective, consecutive cohort of patients reflect a greater incidence of serum IgE positivity compared to historical figures. When utilised with clinical findings on history and examination, serum IgE is a useful adjunct that is associated with greater residual symptoms post\u2010adenotonsillectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15430","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T09:36:06Z","timestamp":1615196166000},"page":"1228-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of allergen\u2010specific and total <scp>immunoglobulin E<\/scp> positivity in children undergoing adenotonsillectomy"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-0847","authenticated-orcid":false,"given":"Matthew E","family":"Lam","sequence":"first","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"},{"name":"Illawarra Health Medical Research Institute University of Wollongong  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Kitipornchai","sequence":"additional","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natelle","family":"Ball","sequence":"additional","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lernik","family":"Sarkissian","sequence":"additional","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Sands","sequence":"additional","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Grundy","sequence":"additional","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart G","family":"MacKay","sequence":"additional","affiliation":[{"name":"Illawarra Shoalhaven Local Health District The Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.1.2008171"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3312"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23323"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.04.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1388"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.01.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-01-18-4476"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21123"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20075"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21529"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06707.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(99)00009-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00668.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880260022005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2017.00500"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.08.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1997.tb00156.x"},{"key":"e_1_2_8_22_1","first-page":"83","article-title":"Sleep\u2010disordered breathing in children with asthma: A systematic review on the impact of treatment","volume":"9","author":"S\u00e1nchez T","year":"2016","journal-title":"J. Asthma Allergy"},{"key":"e_1_2_8_23_1","first-page":"1736","article-title":"Montelukast for children with obstructive sleep apnea: Results of a double\u2010blind, randomized, placebo\u2010controlled trial","volume":"13","author":"Kheirandish\u2010Gozal L","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817742597"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2382"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.15430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:03:16Z","timestamp":1692666196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.15430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jpc.15430"],"URL":"https:\/\/doi.org\/10.1111\/jpc.15430","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"type":"print","value":"1034-4810"},{"type":"electronic","value":"1440-1754"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"2020-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}