{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:43Z","timestamp":1791499543673,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201612013"],"award-info":[{"award-number":["SZSM201612013"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of topical steroid (0.1% mometasone furoate) therapy and factors affecting long\u2010term outcome of paediatric severe phimosis in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1550 patients with severe phimosis classified by Kikiros system were prospectively enrolled in the study from January 2016 to February 2020. They were prescribed with 0.1% mometasone furoate twice a day for 4\u2009weeks. Patients were re\u2010evaluated at the end of weeks 2, 4, 8 and 6\u00a0months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1499 patients completed the treatment, 71.1% responded at the end of week 4. The long\u2010term success rate was 66.0% over a mean follow\u2010up of 26.9\u00a0months. The success rate of grade 4 phimosis was significantly higher than that of grade 5 at 4, 8\u2009weeks and 6\u00a0months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively). Patients with balanoposthitis had a poorer outcome compared with patients without symptoms and patients symptoms by prepuce ballooning or urinary tract infections (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Initial grade of 5 phimosis and symptom with balanoposthitis were independent risk factors for recurrence. All patients had no systemic side effects, 23 cases developed local erythema or burning sensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical steroid (0.1% mometasone furoate) is an effective treatment for severe phimosis in children. The recurrence was related to the grade or symptoms of severe phimosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15628","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T09:50:14Z","timestamp":1625219414000},"page":"1960-1965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of topical steroid treatment in children with severe phimosis in China: A long\u2010term single centre prospective study"],"prefix":"10.1111","volume":"57","author":[{"given":"Guanglun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Urology and Laboratory of Pelvic Floor Muscle Function Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology and Laboratory of Pelvic Floor Muscle Function Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology and Laboratory of Pelvic Floor Muscle Function Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-0283","authenticated-orcid":false,"given":"Shoulin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology and Laboratory of Pelvic Floor Muscle Function Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.03.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68112-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1996.tb02554.x"},{"key":"e_1_2_8_5_1","first-page":"925","article-title":"Topical corticosteroids for treating phimosis in boys","volume":"2","author":"Moreno G","year":"2014","journal-title":"Cochrane Database Syst. 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