{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:59:27Z","timestamp":1781603967928,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Penicillin allergy labels are frequently encountered in children and are associated with significant harms. Most children are falsely labelled and can safely tolerate a penicillin but delabelling strategies are underutilised and paediatric\u2010specific resources are lacking. The aim of this study was to evaluate an allergy assessment tool for children in hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated a paediatric\u2010adapted penicillin allergy assessment tool, using an online survey of clinicians in a tertiary paediatric hospital, with 10 hypothetical potential penicillin allergy or adverse reaction cases (including non\u2010allergy reactions). For each case, respondents were asked to use the tool to assign a reaction phenotype and recommend management. We determined the tool's sensitivity, specificity and acceptability to end users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We evaluated 30 complete survey responses from senior and junior medical staff, nurses and pharmacists. The tool's overall sensitivity was 80.7% (95% confidence interval (CI) 74.2\u201387.1%) for assigning the correct reaction phenotype and 85.3% (95% CI 79.4\u201391.3%) for appropriate management. The tool had high sensitivity for identifying immediate hypersensitivity reactions at 95.6% (95% CI 90.2\u2013100%). Most respondents agreed or strongly agreed that they would use the tool in their practice (22\/30, 73.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This survey evaluated a paediatric\u2010adapted penicillin allergy assessment tool in a tertiary paediatric hospital among multidisciplinary clinician groups. The tool performed well overall and had high safety in identifying immediate hypersensitivity reactions. Further research to support implementation of allergy assessment and delabelling programmes among children is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15657","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:43:36Z","timestamp":1627559016000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>ESCAPE\u2010Allergy<\/scp>: Evaluating screening for children and adolescents with penicillin allergy"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-3644","authenticated-orcid":false,"given":"Kobi J","family":"Rischin","sequence":"first","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-7765","authenticated-orcid":false,"given":"Mona","family":"Mostaghim","sequence":"additional","affiliation":[{"name":"Pharmacy Department Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Rao","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales  Sydney New South Wales Australia"},{"name":"Emergency Department Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Smith","sequence":"additional","affiliation":[{"name":"Kids Cancer Centre Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey A","family":"O'Brien","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales  Sydney New South Wales Australia"},{"name":"Kids Cancer Centre Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A","family":"Trubiano","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases Austin Health  Melbourne Victoria Australia"},{"name":"National Centre for Infections in Cancer Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Frith","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Immunology and Infectious Diseases Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-3416","authenticated-orcid":false,"given":"Brendan","family":"McMullan","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Heath University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Immunology and Infectious Diseases Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.09.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.01.034"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.12.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01169.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.9.8.722"},{"key":"e_1_2_7_9_1","unstructured":"eTG Complete.Antimicrobial hypersensitivity.Antibiotics. 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