{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:38:34Z","timestamp":1747186714719,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if the management of paediatric status epilepticus (SE) follows accepted clinical practice guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, consecutive series of patients with SE who attended the emergency departments from two NSW sites over a 12\u2010month period. SE was defined as a convulsive seizure, 5\u00a0min or more in duration. Time to presentation to the ED, time to first\u2010 and second\u2010line treatment, number of benzodiazepine (BZD) doses given prior to intubation and adherence to guidelines were evaluated. The outcomes included seizure duration, need for respiratory support, admission to intensive care, morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The time from onset of seizure to ED presentation was a median (p25\u2013p75) time of 22 (15\u201340) min. Forty\u2010eight of 59 presentations received pre\u2010hospital midazolam. The median (p25\u2013p75) time to first\u2010line treatment was 15 (8\u201325) min and to second\u2010line treatment was 43.5 (35\u201359) min. There was no significant difference in the results in the two hospitals. The total number of BZD doses ranged from 1 to 7 (median 3). There was non\u2010adherence to the clinical practice guidelines in 55 (93.2%) of 59 presentations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found excessive benzodiazepine use and delay in both definitive treatment of status epilepticus and in escalation from first\u2010 to second\u2010line anticonvulsant treatment. This raises the need for rapid escalation of treatment. We propose a \u2018status epilepticus code\u2019 for emergency departments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15697","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T09:16:20Z","timestamp":1629105380000},"page":"261-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The need for improved management of status epilepticus in children in Australia: Time from seizure onset to treatment is consistently delayed"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5776-5483","authenticated-orcid":false,"given":"Preena","family":"Uppal","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology Sydney Children's Hospital Randwick New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cardamone","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Sydney Children's Hospital Randwick New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"Fonseca","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Paediatrics St George Hospital Kogarah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Briggs","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"A Lawson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Sydney Children's Hospital Randwick New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69043-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.04.005"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4382"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001673"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.3_Part_1.483"},{"key":"e_1_2_5_7_1","unstructured":"Children and Infants with Seizures \u2010 Acute Management.Clinical practice guidelines \u2010 NSW health;2009."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000258355.23810.c6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12235"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1684\/epd.2007.0069","article-title":"Treatment adherence and outcomes in the management of convulsive status epilepticus in the emergency room","volume":"9","author":"Muayqil T","year":"2007","journal-title":"Epileptic Disord."},{"key":"e_1_2_5_11_1","first-page":"63","article-title":"Effect of treatment of convulsive status epilepticus on outcome in children","volume":"231","author":"Shatirishvili T","year":"2014","journal-title":"Georgian Med. 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