{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:47:02Z","timestamp":1759178822587,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Although chest computed tomography (CT) score has been well evaluated in adult coronavirus disease (COVID\u201019), its use in paediatric cases is insufficiently studied. Our aim is to evaluate the relationship of chest CT score with disease severity and laboratory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010six paediatric patients with confirmed COVID\u201019 and chest CT evaluation on admission have been included in this study. Chest CT score was calculated for each of the five lobes considering the extent of anatomical involvement, as follows: 0: 0%; 1: &lt;5%; 2: 5%\u201325%; 3: 26%\u201350%; 4: 51%\u201375% and 5: &gt;75%. The resulting total CT score was the sum of each individual lobar score; the range was between 0 and 25.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total chest CT score was found to be positively correlated with alanine aminotransferase and <jats:sc>d<\/jats:sc>\u2010dimer, and negatively correlated with lymphocyte count. In receiver operating characteristic analysis, total chest CT score had area under the curve 0.99 (95% confidence interval, 0.98\u20131.00) at cut\u2010off 2 with 95% sensitivity and 96% specificity for the severe disease. Furthermore, in\u2010depth analysis of lobar CT scores showed a correlation between left upper lobe with lymphocyte count, left lower lobe with <jats:sc>d<\/jats:sc>\u2010dimer, right middle and lower lobes with alanine aminotransferase and right upper lobe with leukocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a significant relationship between chest CT score and COVID\u201019 severity and laboratory findings in children. This suggests that chest CT scores can be used to assess the severity of the disease and can play an important role in paediatric clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15839","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T18:39:33Z","timestamp":1639420773000},"page":"802-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship of chest computed tomography score with disease severity and laboratory values in children with <scp>COVID<\/scp>\u201019"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-7523","authenticated-orcid":false,"given":"Ceren","family":"\u00c7etin","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases University of Health Sciences, Kartal Dr Lutfi K\u0131rdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Karaaslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases University of Health Sciences, Kartal Dr Lutfi K\u0131rdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Ak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Health Sciences, Kartal Dr Lutfi K\u0131rdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meral","family":"Arifoglu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Health Sciences, Kartal Dr Lutfi K\u0131rdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnay","family":"Rona","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Health Sciences, Kartal Dr Lutfi K\u0131rdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Demirhan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery University of Health Sciences, Kartal Dr Lutfi K\u0131rdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000044"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Naming the coronavirus disease (COVID\u201019) and the virus that causes it. 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