{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:38:49Z","timestamp":1747186729788,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The standard serological test to screen for coeliac disease (CD) is tissue transglutaminase (tTG) but some experts recommend including deamidated gliadin peptide (DGP) antibodies for children younger than 3\u2009years old. This study evaluated the utility of DGP\u2010immunoglobulin A (IgA) and DGP\u2010immunoglobulin G (IgG) serologies when screening children younger than 3\u2009years old for CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted including children 3\u2009years old and under, who had DGP and\/or tTG serologies along with duodenal biopsies during their initial diagnostic evaluation. Serology results were compared to the gold\u2010standard histopathology by \u03c7<jats:sup>2<\/jats:sup> to determine the significance of including DGP\u2010IgG\/IgA serologies when screening for CD in this age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 478 patients, 52 who were younger than 3\u2009years old, 43 of whom met inclusion criteria. The positive predictive value (PPV) of the DGP\u2010IgA test was 91.7% whereas, DGP\u2010IgG was 77.8%. When DGP serology was examined in conjunction with tTG\u2010IgA, the PPV with DGP\u2010IgA was 90.9% and with DGP\u2010IgG was 87.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In isolation, DGP\u2010IgA provides a high PPV and specificity for CD in children younger than 3\u2009years old, whereas DGP\u2010IgG had a much lower PPV in this age group. When used alone or in conjunction with tTG\u2010IgA, the DGP\u2010IgA test results in a high PPV of 91.7 and 90.9%, respectively. Based on our study, we recommend obtaining both the DGP\u2010IgA and the tTG\u2010IgA serology when screening infants and children younger than 3\u2009years old for coeliac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15845","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T08:11:14Z","timestamp":1638778274000},"page":"815-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Usefulness of deamidated gliadin peptide antibodies in diagnosing coeliac disease in children younger than 3\u2009years old"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3992-2251","authenticated-orcid":false,"given":"Madison","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology and Nutrition University of Maryland Medical Center  Baltimore Maryland United 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Gastroenterology and Nutrition University of Maryland Medical Center  Baltimore Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Kader","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology and Nutrition University of Maryland Medical Center  Baltimore Maryland United 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